miRNAs at the interface of cellular stress and disease

被引：88

作者：

Emde, Anna ^{[1
]}

Hornstein, Eran ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, Israel

来源：

EMBO JOURNAL | 2014年 / 33卷 / 13期

基金：

以色列科学基金会;

关键词：

cellular stress; dicer; disease; micrornas; stress granules; ENDOPLASMIC-RETICULUM STRESS; RNA-BINDING PROTEIN; LENGTH POLYGLUTAMINE EXPANSIONS; MENTAL-RETARDATION PROTEIN; MICRORNA EXPRESSION; ER STRESS; LIFE-SPAN; INITIATION FACTOR-2-ALPHA; ATAXIN-2; INTERACTS; ENDOGENOUS TDP-43;

D O I：

10.15252/embj.201488142

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

microRNAs (miRNAs) are a family of small, non-coding RNAs, which provides broad silencing activity of mRNA targets in a sequence-dependent fashion. This review explores the hypothesis that the miRNA machinery is intimately linked with the cellular stress pathway and apparatus. Stress signaling potentially alters the function of the miRNA-bioprocessing core components and decompensates regulation. In addition, dysregulation of miRNA activity renders the cell more prone to stress and emerges as a new pathway for age-related insults and diseases, such as neurodegeneration.

引用

页码：1428 / 1437

页数：10

共 133 条

[1] The epidemiology of ALS: a conspiracy of genes, environment and time [J].

Al-Chalabi, Ammar ;

Hardiman, Orla .

NATURE REVIEWS NEUROLOGY, 2013, 9 (11) :617-628

[2] Many Families of C. elegans MicroRNAs Are Not Essential for Development or Viability [J].

Alvarez-Saavedra, Ezequiel ;

Horvitz, H. Robert .

CURRENT BIOLOGY, 2010, 20 (04) :367-373

[3] RNA granules [J].

Anderson, P ;

Kedersha, N .

JOURNAL OF CELL BIOLOGY, 2006, 172 (06) :803-808

[4] Stress granules: The Tao of RNA triage [J].

Anderson, Paul ;

Kedersha, Nancy .

TRENDS IN BIOCHEMICAL SCIENCES, 2008, 33 (03) :141-150

[5] RETRACTED: Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis (Retracted Article) [J].

Atkin, Julie D. ;

Farg, Manal A. ;

Walker, Adam K. ;

McLean, Catriona ;

Tomas, Doris ;

Horne, Malcolm K. .

NEUROBIOLOGY OF DISEASE, 2008, 30 (03) :400-407

[6] Endogenous TDP-43, but not FUS, contributes to stress granule assembly via G3BP [J].

Aulas, Anais ;

Stabile, Stephanie ;

Velde, Christine Vande .

MOLECULAR NEURODEGENERATION, 2012, 7

[7] Amyotrophic lateral sclerosis-linked FUS/TLS alters stress granule assembly and dynamics [J].

Baron, Desiree M. ;

Kaushansky, Laura J. ;

Ward, Catherine L. ;

Sama, Reddy Ranjith K. ;

Chian, Ru-Ju ;

Boggio, Kristin J. ;

Quaresma, Alexandre J. C. ;

Nickerson, Jeffrey A. ;

Bosco, Daryl A. .

MOLECULAR NEURODEGENERATION, 2013, 8

[8] MicroRNAs: Target Recognition and Regulatory Functions [J].

Bartel, David P. .

CELL, 2009, 136 (02) :215-233

[9] A developmental timing microRNA and its target regulate life span in C. elegans [J].

Boehm, M ;

Slack, F .

SCIENCE, 2005, 310 (5756) :1954-1957

[10] Mutant FUS proteins that cause amyotrophic lateral sclerosis incorporate into stress granules [J].

Bosco, Daryl A. ;

Lemay, Nathan ;

Ko, Hae Kyung ;

Zhou, Hongru ;

Burke, Chris ;

Kwiatkowski, Thomas J., Jr. ;

Sapp, Peter ;

McKenna-Yasek, Diane ;

Brown, Robert H., Jr. ;

Hayward, Lawrence J. .

HUMAN MOLECULAR GENETICS, 2010, 19 (21) :4160-4175

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