Graft Steatosis as a Risk Factor of Ischemic-Type Biliary Lesions in Liver Transplantation

被引：28

作者：

Frongillo, F. ^{[1
]}

Lirosi, M. C. ^{[1
]}

Sganga, G. ^{[1
]}

Grossi, U. ^{[1
]}

Nure, E. ^{[1
]}

Avolio, A. W. ^{[1
]}

Bianco, G. ^{[1
]}

Mariano, G. ^{[1
]}

Agnes, S. ^{[1
]}

机构：

[1] Univ Cattolica Sacro Cuore, Dept Surg, Transplantat Serv, I-00168 Rome, Italy

来源：

TRANSPLANTATION PROCEEDINGS | 2014年 / 46卷 / 07期

关键词：

COMPLICATIONS; STRICTURES;

D O I：

10.1016/j.transproceed.2014.07.057

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Ischemic-type biliary lesions (ITBLs) are now a discussed cause of morbidity and mortality in liver transplant recipients, even if not definitively characterized. We reviewed 13 years of donor and recipient data between April 2001 and April 2013. We evaluated the incidence of ITBL occurrence, exploring the possible predisposing factors, focusing on the relationship between severe macrovesicular steatosis of the graft and incidence of ITBL. A total of 445 grafts were harvested: 416 of them were transplanted at our institution, the remaining 29 were discarded by our donor team as showing more than 40% macrovesicular steatosis. Mild-moderate (20% to 40%) macrovesicular steatosis (P < .001) and cold ischemia time (P = .048) significantly increased the risk of ITBLs, also resulting in independent risk factors at multivariate analysis.

引用

页码：2293 / 2294

页数：2

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