Incidence of chromosome 21 disomy in human spermatozoa as determined by fluorescent in-situ hybridization

被引：0

作者：

Blanco, J ^{[1
]}

Egozcue, J ^{[1
]}

Vidal, F ^{[1
]}

机构：

[1] UNIV AUTONOMA BARCELONA,FAC CIENCIES,UNITAT BIOL CELLULAR,E-08193 BELLATERRA,SPAIN

来源：

HUMAN REPRODUCTION | 1996年 / 11卷 / 04期

关键词：

chromosome; 21; disomy; spermatozoa;

D O I：

暂无

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

We have evaluated the incidence of chromosome 21 disomy in decondensed sperm heads from nine normal men using a locus-specific DNA probe for chromosome 21, and a centromeric probe for chromosome 6 as a control, The results show that the incidence of chromosome 21 disomy (0.38%) is significantly higher than disomy for chromosome 6 (0.14%). No differences were found among the individuals analysed.

引用

页码：722 / 726

页数：5

共 36 条

[1]

ANTONARAKIS S E, 1986, P185

[2] HUMAN CHROMOSOME-21 - GENOME MAPPING AND EXPLORATION, CIRCA 1993 [J].

ANTONARAKIS, SE .

TRENDS IN GENETICS, 1993, 9 (04) :142-148

[3] ESTIMATES OF ANEUPLOIDY USING MULTICOLOR FLUORESCENCE IN-SITU HYBRIDIZATION ON HUMAN SPERM [J].

BISCHOFF, FZ ;

NGUYEN, DD ;

BURT, KJ ;

SHAFFER, LG .

CYTOGENETICS AND CELL GENETICS, 1994, 66 (04) :237-243

[4] INCIDENCE OF LOW-FLUORESCENCE A SATELLITE REGION ON CHROMOSOME-21 ESCAPING DETECTION OF ANEUPLOIDY AT INTERPHASE BY FISH [J].

BOSSUYT, PJ ;

VANTIENEN, MN ;

DEGRUYTER, L ;

SMETS, V ;

DUMON, J ;

WAUTERS, JG .

CYTOGENETICS AND CELL GENETICS, 1995, 68 (3-4) :203-206

[5]

CHEVRET E, 1994, HUM GENET, V94, P701

[6] NONISOTOPIC INSITU HYBRIDIZATION AS A METHOD FOR NONDISJUNCTION STUDIES IN HUMAN SPERMATOZOA [J].

COONEN, E ;

PIETERS, MHEC ;

DUMOULIN, JCM ;

MEYER, H ;

EVERS, JLH ;

RAMAEKERS, FCS ;

GERAEDTS, JPM .

MOLECULAR REPRODUCTION AND DEVELOPMENT, 1991, 28 (01) :18-22

[7]

FORD E, 1973, HUMAN CHROMOSOMES

[8]

Goldman A. S. H., 1993, European Journal of Human Genetics, V1, P325

[9]

GUTTENBACH M, 1994, HUM GENET, V93, P7

[10]

GUTTENBACH M, 1990, AM J HUM GENET, V46, P553

← 1 2 3 4 →