The pathology of multiple sclerosis and its evolution

被引：58

作者：

Lassmann, H ^{[1
]}

机构：

[1] Univ Vienna, Brain Res Inst, Dept Neuroimmunol, A-1090 Vienna, Austria

来源：

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES | 1999年 / 354卷 / 1390期

关键词：

multiple sclerosis; pathology; immunology;

D O I：

10.1098/rstb.1999.0508

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The pathology of multiple sclerosis (MS) was defined more than a century ago as a chronic inflammatory process which is associated with widespread primary demyelination and glial scarring. In this short review we discuss controversial issues on (i) the relationship between inflammation and demyelination, (ii) the various possible mechanisms of myelin destruction, and (iii) axonal involvement in this disease. We suggest that the disease process of MS is more complex that previously believed.

引用

页码：1635 / 1640

页数：6

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