Resveratrol attenuates left ventricular remodeling in old rats with COPD induced by cigarette smoke exposure and LPS instillation

被引:23
|
作者
Hu, Yi Xin [1 ]
Cui, Hua [2 ]
Fan, Li [1 ]
Pan, Xiu Jie [3 ]
Wu, Ji Hua [4 ]
Shi, Suo Zhu [5 ,6 ]
Cui, Shao Yuan [5 ,6 ]
Wei, Zhi Min [1 ]
Liu, Lin [2 ]
机构
[1] Peoples Liberat Army Gen Hosp, Dept Hlth Care Nanlou, Beijing, Peoples R China
[2] Peoples Liberat Army Gen Hosp, Geriatr Cardiol Div 2, Beijing, Peoples R China
[3] Peoples Liberat Army Gen Hosp, Beijing Inst Radiat Med, Dept Radiat Toxicol & Oncol, Beijing, Peoples R China
[4] Peoples Liberat Army Gen Hosp, Dept Pathol, Beijing, Peoples R China
[5] Peoples Liberat Army Gen Hosp, Kidney Ctr Chinese PA, Div Nephrol, Beijing, Peoples R China
[6] Peoples Liberat Army Gen Hosp, Key Lab, Beijing, Peoples R China
关键词
resveratrol; COPD; oxidative stress; sirtuin; 1; ventricular remodeling; OBSTRUCTIVE PULMONARY-DISEASE; NF-KAPPA-B; INDUCED MYOCARDIAL DYSFUNCTION; CHRONIC HEART-FAILURE; SMOOTH-MUSCLE-CELLS; OXIDATIVE STRESS; INFLAMMATORY CYTOKINES; CARDIOVASCULAR-DISEASE; HYPERTENSIVE-RATS; ANIMAL-MODELS;
D O I
10.1139/cjpp-2012-0464
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The objective of this study was to investigate left cardiac damage and the cardioprotective effects of resveratrol in old rats with COPD. Rats 22 months old were divided into three groups: control (CTL), smoking and lipopolysaccharides (SM/LPS), and SM/LPS plus resveratrol (SM/LPS-Res). Cardiac function, pathology, oxidative stress, and apoptosis index were measured. Expression of myocardial SIRT1 was studied by real-time quantitative polymerase chain reaction (PCR) and Western blot detection. The heart weight - body weight ratio (LVW/BW) increased in the SM/LPS group compared with the CTL group. Both the LVW/BW and the area of fibrosis in the SM/LPS-Res group decreased compared with those in the SM/LPS group. 8-OHdG expression increased in cardiac tissue of rats in the SM/LPS group, which could be inhibited by resveratrol. Resveratrol significantly increased the activity of superoxide dismutase (SOD) and reduced the cardiac malonyldialdehyde (MDA) level in the SM/LPS-Res group. There was a significant decrease in the extent of cardiomyocyte apoptosis in the SM/LPS-Res group compared with the SM/LPS group. SIRT1 mRNA increased in the SM/LPS-Res group compared with the SM/LPS group. In conclusion, resveratrol attenuated cardiac oxidative damage and left ventricular remodeling and enhanced the decreased expression of SIRT1 in hearts of old rats with emphysema and thus might be a therapeutic modality for cardiac injury complicated in chronic obstructive pulmonary disease (COPD).
引用
收藏
页码:1044 / 1054
页数:11
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