Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor

被引：581
作者：
Paresce, DM
Ghosh, RN
Maxfield, FR
机构：
[1] COLUMBIA UNIV, DEPT BIOL, NEW YORK, NY 10032 USA
[2] COLUMBIA UNIV, ALZHEIMERS DIS RES CTR, NEW YORK, NY 10032 USA
[3] COLUMBIA UNIV, CTR NEUROBIOL & BEHAV, NEW YORK, NY 10032 USA
[4] CORNELL UNIV, COLL MED, DEPT BIOCHEM, NEW YORK, NY 10021 USA
来源：
NEURON | 1996年 / 17卷 / 03期
关键词：
D O I：
10.1016/S0896-6273(00)80187-7
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Microglia are immune system cells associated with Alzheimer's disease plaques containing beta-amyloid (A beta). Murine microglia internalize microaggregates of fluorescently labeled or radioiodinated A beta peptide 1-42. Uptake was confirmed using aggregates of unlabeled A beta detected by immunofluorescence. Uptake of A beta was reduced by coincubation with excess acetyl-low density lipoprotein (Ac-LDL) or other scavenger receptor (SR) ligands, and Dil-labeled Ac-LDL uptake by microglia was blocked by excess A beta. CHO cells transfected with class A or B SRs showed significantly enhanced uptake of A beta. These results show that microglia express SRs that may play a significant role in the clearance of A beta plaques. Binding to SRs could activate inflammation responses that contribute to the pathology of Alzheimer's disease.
引用
收藏
页码：553 / 565
页数：13
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