Maternal intake of vitamins A, E and K in pregnancy and child allergic disease: a longitudinal study from the Danish National Birth Cohort

被引:43
|
作者
Maslova, Ekaterina [1 ]
Hansen, Susanne [1 ]
Strom, Marin [1 ]
Halldorsson, Thorhallur I. [1 ,2 ,3 ]
Olsen, Sjurdur F. [1 ,4 ]
机构
[1] Statens Serum Inst, Dept Epidemiol Res, Ctr Fetal Programming, DK-2300 Copenhagen, Denmark
[2] Univ Iceland, Sch Hlth Sci, Fac Food Sci & Nutr, Reykjavik, Iceland
[3] Landspitali Univ Hosp, Unit Nutr Res, Reykjavik, Iceland
[4] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA
基金
英国医学研究理事会; 新加坡国家研究基金会;
关键词
Asthma; Allergic rhinitis; Fat-soluble vitamins; Pregnancy; Cohort studies; ANTIOXIDANT INTAKE; A SUPPLEMENTATION; DIETARY FACTORS; IMMUNE FUNCTION; ASTHMA; PREVALENCE; REGRESSION; RISK; CONSUMPTION; DEFICIENCY;
D O I
10.1017/S0007114513003395
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Fat-soluble vitamins A, E and K have been shown to play roles in immunity and inflammation, but studies on child allergic disease have been few and inconsistent. The aim of the present study was to examine the relationship between maternal intake of vitamins A, E and K in mid-pregnancy and child asthma and allergic rhinitis. We used data on 44594 mother-child pairs from the Danish National Birth Cohort. Maternal intake of fat-soluble vitamins was calculated based on the information from a validated FFQ completed in mid-pregnancy. At 18 months, interviews with the mothers were conducted to evaluate doctor-diagnosed child asthma. At age 7 years, we assessed child asthma and allergic rhinitis using questions from the International Study of Asthma and Allergies in Childhood questionnaire and by national registries on hospital contacts and medication use. Current asthma was defined as asthma diagnosis and wheeze in the past 12 months by maternal report. We calculated multivariable risk ratios and 95% CI by comparing the highest v. lowest quintile (Q) of maternal vitamin A, E and K intake in relation to child allergic disease outcomes. Maternal total vitamin K intake was directly associated with ever admitted asthma (Q5 v. Q1: 1 center dot 23, 95% CI 1 center dot 01, 1 center dot 50) and current asthma at 7 years (Q5 v. Q1: 1 center dot 30, 95% CI 0 center dot 99, 1 center dot 70). Weak inverse associations were present for maternal vitamin A and E intake during pregnancy with child allergic rhinitis. Maternal vitamin K intake during pregnancy may increase the risk of child asthma, and should be explored further on a mechanistic level. Conversely, maternal vitamin A and E intake may protect against child allergic rhinitis.
引用
收藏
页码:1096 / 1108
页数:13
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