Maternal intake of vitamins A, E and K in pregnancy and child allergic disease: a longitudinal study from the Danish National Birth Cohort

被引:43
|
作者
Maslova, Ekaterina [1 ]
Hansen, Susanne [1 ]
Strom, Marin [1 ]
Halldorsson, Thorhallur I. [1 ,2 ,3 ]
Olsen, Sjurdur F. [1 ,4 ]
机构
[1] Statens Serum Inst, Dept Epidemiol Res, Ctr Fetal Programming, DK-2300 Copenhagen, Denmark
[2] Univ Iceland, Sch Hlth Sci, Fac Food Sci & Nutr, Reykjavik, Iceland
[3] Landspitali Univ Hosp, Unit Nutr Res, Reykjavik, Iceland
[4] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA
基金
英国医学研究理事会; 新加坡国家研究基金会;
关键词
Asthma; Allergic rhinitis; Fat-soluble vitamins; Pregnancy; Cohort studies; ANTIOXIDANT INTAKE; A SUPPLEMENTATION; DIETARY FACTORS; IMMUNE FUNCTION; ASTHMA; PREVALENCE; REGRESSION; RISK; CONSUMPTION; DEFICIENCY;
D O I
10.1017/S0007114513003395
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Fat-soluble vitamins A, E and K have been shown to play roles in immunity and inflammation, but studies on child allergic disease have been few and inconsistent. The aim of the present study was to examine the relationship between maternal intake of vitamins A, E and K in mid-pregnancy and child asthma and allergic rhinitis. We used data on 44594 mother-child pairs from the Danish National Birth Cohort. Maternal intake of fat-soluble vitamins was calculated based on the information from a validated FFQ completed in mid-pregnancy. At 18 months, interviews with the mothers were conducted to evaluate doctor-diagnosed child asthma. At age 7 years, we assessed child asthma and allergic rhinitis using questions from the International Study of Asthma and Allergies in Childhood questionnaire and by national registries on hospital contacts and medication use. Current asthma was defined as asthma diagnosis and wheeze in the past 12 months by maternal report. We calculated multivariable risk ratios and 95% CI by comparing the highest v. lowest quintile (Q) of maternal vitamin A, E and K intake in relation to child allergic disease outcomes. Maternal total vitamin K intake was directly associated with ever admitted asthma (Q5 v. Q1: 1 center dot 23, 95% CI 1 center dot 01, 1 center dot 50) and current asthma at 7 years (Q5 v. Q1: 1 center dot 30, 95% CI 0 center dot 99, 1 center dot 70). Weak inverse associations were present for maternal vitamin A and E intake during pregnancy with child allergic rhinitis. Maternal vitamin K intake during pregnancy may increase the risk of child asthma, and should be explored further on a mechanistic level. Conversely, maternal vitamin A and E intake may protect against child allergic rhinitis.
引用
收藏
页码:1096 / 1108
页数:13
相关论文
共 50 条
  • [11] Maternal thyroid disease in the Danish National Birth Cohort: prevalence and risk factors
    Andersen, Stine Linding
    Olsen, Jorn
    Laurberg, Peter
    EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2016, 174 (02) : 203 - 212
  • [12] Intake of fish oil in early pregnancy and foetal growth: A sub-study of the Danish National Birth Cohort
    Knudsen, VK
    Olsen, SF
    PEDIATRIC RESEARCH, 2003, 53 (06) : 45A - 45A
  • [13] Maternal Dietary Patterns during Pregnancy in Relation to Offspring Forearm Fractures: Prospective Study from the Danish National Birth Cohort
    Petersen, Sesilje B.
    Rasmussen, Morten A.
    Olsen, Sjurdur F.
    Vestergaard, Peter
    Molgaard, Christian
    Halldorsson, Thorhallur I.
    Strom, Marin
    NUTRIENTS, 2015, 7 (04): : 2382 - 2400
  • [14] Intake of fish in early and mid-pregnancy and risk of preeclampsia: a study within the Danish National Birth Cohort
    Halldorsson, T. I.
    Strom, M.
    Thorne-Lyman, A. L.
    Olsen, S. F.
    ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 2013, 92 : 16 - 17
  • [15] Maternal pre-pregnancy BMI and reproductive health in adult sons: a study in the Danish National Birth Cohort
    Gaml-Sorensen, Anne
    Thomsen, Anne Hjorth
    Tottenborg, Sandra Sogaard
    Brix, Nis
    Hougaard, Karin Sorig
    Toft, Gunnar
    Haberg, Siri Eldevik
    Myrskyla, Mikko
    Bonde, Jens Peter
    Ramlau-Hansen, Cecilia Host
    HUMAN REPRODUCTION, 2024, 39 (01) : 219 - 231
  • [16] Dietary patterns and the risk of pregnancy-associated hypertension in the Danish National Birth Cohort: a prospective longitudinal study
    Ikem, E.
    Halldorsson, T. I.
    Birgisdottir, B. E.
    Rasmussen, M. A.
    Olsen, S. F.
    Maslova, E.
    BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2019, 126 (05) : 663 - 673
  • [17] Comparison of associations of maternal peri-pregnancy and paternal anthropometrics with child anthropometrics from birth through age 7 y assessed in the Danish National Birth Cohort
    Sorensen, Thorkild I. A.
    Ajslev, Teresa Adeltoft
    Angquist, Lars
    Morgen, Camilla Schmidt
    Ciuchi, Ioana Gabriela
    Smith, George Davey
    AMERICAN JOURNAL OF CLINICAL NUTRITION, 2016, 104 (02): : 389 - 396
  • [18] Perfluoroalkyl Substances and Maternal Thyroid Hormones in Early Pregnancy; Findings in the Danish National Birth Cohort
    Inoue, Kosuke
    Ritz, Beate
    Andersen, Stine Linding
    Ramlau-Hansen, Cecilia Host
    Hoyer, Birgit Bjerre
    Bech, Bodil Hammer
    Henriksen, Tine Brink
    Bonefeld-Jorgensen, Eva Cecilie
    Olsen, Jorn
    Liew, Zeyan
    ENVIRONMENTAL HEALTH PERSPECTIVES, 2019, 127 (11)
  • [19] Subfecundity and neonatal mortality: longitudinal study within the Danish national birth cohort
    Basso, O
    Olsen, J
    BRITISH MEDICAL JOURNAL, 2005, 330 (7488): : 393 - 394
  • [20] Thrombophilias and adverse pregnancy outcomes: results from the Danish National Birth Cohort
    Lykke, J. A.
    Bare, L. A.
    Olsen, J.
    Lagier, R.
    Arellano, A. R.
    Tong, C.
    Paidas, M. J.
    Langhoff-Roos, J.
    JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2012, 10 (07) : 1320 - 1325