The Clinical Significance of DNA Damage Repair Signatures in Clear Cell Renal Cell Carcinoma

被引：10

作者：

Guo, Ergang ^{[1
]}

Wu, Cheng ^{[1
]}

Ming, Jun ^{[1
]}

Zhang, Wei ^{[1
]}

Zhang, Linli ^{[1
]}

Hu, Guoqing ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Dept Oncol, Tongji Med Coll, Tongji Hosp, Wuhan, Hubei, Peoples R China

来源：

FRONTIERS IN GENETICS | 2021年 / 11卷

基金：

中国国家自然科学基金;

关键词：

DNA damage; DNA repair; clear cell renal cell carcinoma; urology; immunotherapy; cancer; TUMOR-ASSOCIATED NEUTROPHILS; BREAST-CANCER; RESISTANCE; APOPTOSIS; PATHWAY; MARKERS; GROWTH;

D O I：

10.3389/fgene.2020.593039

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

DNA damage repair plays an important role in cancer's initiation and progression, and in therapeutic resistance. The prognostic potential of damage repair indicators was studied in the case of clear cell renal cell carcinoma (ccRCC). Gene expression profiles of the disease were downloaded from cancer genome databases and gene ontology was applied to the DNA repair-related genes. Twenty-six differentially expressed DNA repair genes were identified, and regression analysis was used to identify those with prognostic potential and to construct a risk model. The model accurately predicted patient outcomes and distinguished among patients with different expression levels of immune evasion genes. The data indicate that DNA repair genes can be valuable for predicting the progression of clear cell renal cell carcinoma and the clinical benefits of immunotherapy.

引用

页数：11

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