Current Insights and Latest Updates in Sperm Motility and Associated Applications in Assisted Reproduction

被引：99
作者：
Dcunha, Reyon [1 ]
Hussein, Reda S. [2 ,3 ]
Ananda, Hanumappa [1 ]
Kumari, Sandhya [1 ]
Adiga, Satish Kumar [1 ]
Kannan, Nagarajan [4 ,5 ,6 ]
Zhao, Yulian [2 ,7 ]
Kalthur, Guruprasad [1 ,4 ]
机构：
[1] Manipal Acad Higher Educ, Kasturba Med Coll, Dept Clin Embryol, Manipal 576104, India
[2] Mayo Clin, Dept Obstet & Gynecol, Div Reprod Endocrinol & Infertil, 200 1st St SW, Rochester, MN 55905 USA
[3] Assiut Univ, Dept Obstet & Gynecol, Assiut, Egypt
[4] Mayo Clin, Dept Lab Med & Pathol, Div Expt Pathol & Lab Med, Rochester, MN 55905 USA
[5] Mayo Clin, Ctr Regenerat Med, Rochester, MN 55905 USA
[6] Mayo Clin, Canc Ctr, Rochester, MN 55905 USA
[7] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55905 USA
来源：
REPRODUCTIVE SCIENCES | 2022年 / 29卷 / 01期
关键词：
Assisted reproductive technology; Male infertility; Sperm motility; Sperm motility enhancers; IN-VITRO FERTILIZATION; PROTEIN-TYROSINE PHOSPHORYLATION; CYCLIC ADENOSINE-MONOPHOSPHATE; IDIOPATHIC MALE-INFERTILITY; PLATELET-ACTIVATING-FACTOR; IMPROVES SEMEN QUALITY; HUMAN SPERMATOZOA; SEMINAL PLASMA; ACROSOME REACTION; DOUBLE-BLIND;
D O I：
10.1007/s43032-020-00408-y
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Spermatozoon is a motile cell with a special ability to travel through the woman's reproductive tract and fertilize an oocyte. To reach and penetrate the oocyte, spermatozoa should possess progressive motility. Therefore, motility is an important parameter during both natural and assisted conception. The global trend of progressive reduction in the number and motility of healthy spermatozoa in the ejaculate is associated with increased risk of infertility. Therefore, developing approaches for maintaining or enhancing human sperm motility has been an important area of investigation. In this review we discuss the physiology of sperm, molecular pathways regulating sperm motility, risk factors affecting sperm motility, and the role of sperm motility in fertility outcomes. In addition, we discuss various pharmacological agents and biomolecules that can enhance sperm motility in vitro and in vivo conditions to improve assisted reproductive technology (ART) outcomes. This article opens dialogs to help toxicologists, clinicians, andrologists, and embryologists in understanding the mechanism of factors influencing sperm motility and various management strategies to improve treatment outcomes.
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页码：7 / 25
页数：19
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