Development of a practical synthesis of sumanirole

被引：17

作者：

Wuts, PGM ^{[1
]}

Gu, RL

Northuis, JM

Kwan, TA

Beck, DM

White, MJ

机构：

[1] Pharmacia, Chem Proc Res & Dev, Kalamazoo, MI 49001 USA

[2] Pharmacia, Bioproc & Formulat Technol, Kalamazoo, MI 49001 USA

来源：

PURE AND APPLIED CHEMISTRY | 2002年 / 74卷 / 08期

关键词：

D O I：

10.1351/pac200274081359

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new synthesis of sumanirole that is being developed to treat Parkinson's disease is described. The basic skeleton is constructed from 8-hydroxyquinoline and elaborated to the key tricylic intermediate 14. Further elaboration affords a 1,2-amino alcohol, which is converted to an aziridine by a new process. Finally, dissolving metal reduction to open the aziridine and protecting group removal affords sumanirole.

引用

页码：1359 / 1368

页数：10

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