Synthesis, structural characterization, oxygen sensitivity, and antimicrobial activity of ruthenium(II) carbonyl complexes with thiosemicarbazones

Ru(II) carbonyl complexes were prepared by reacting [Ru(H)(Cl)(CO)(PPh3)(3)] with the respective thiosemicarbazone ligands and the complexes were characterized by UV-vis, FT-IR, and H-1 and P-31 NMR spectroscopy. Oxygen sensitivities and antimicrobial activities of the complexes were determined. [Ru(CO)(PPh3)(2)(eta(3)-O, N-3, S-TSC1)] (1), [Ru(Cl)(CO)(PPh3)(2)(eta(2)-N-3, S-TSC2)] (2), and [Ru(Cl)(CO) (PPh3)2(eta(2)-N-3,S-TSC3)] (3) have been prepared by reacting [Ru(H)(Cl)(CO)(PPh3)(3)] with the respective thiosemicarbazones TSC1 (2-hydroxy-3-methoxybenzaldehyde thiosemicarbazone), TSC2 (3-hydroxybenzaldehyde thiosemicarbazone), and TSC3 (3,4-dihydroxybenzaldehyde thiosemicarbazone) in a 1 : 1 M ratio in toluene and all of the complexes have been characterized by UV-vis, FT-IR, and H-1 and P-31 NMR spectroscopy. The spectroscopic studies showed that TSC1 is coordinated to the central metal as a tridendate ligand coordinating via the azomethine nitrogen (C=N), phenolic oxygen, and sulfur to ruthenium in 1, whereas TSC2 and TSC3 are coordinated to ruthenium as a bidentate ligand through azomethine nitrogen (C=N) and sulfur in 2 and 3. Oxygen sensitivities of 1-3 and [Ru(Cl)(CO)(PPh3)(2)(eta(2)-N-3, S-TSC4)] (4), and antimicrobial activities of 1-3 have been determined.