Serum β2-microglobulin measured by immunonephelometry: expression patterns and reference intervals in healthy adults

被引:16
作者
Matrai, Zoltan [1 ]
Nemeth, Julia [2 ]
Miklos, Katalin [2 ]
Szabo, Zsofia [2 ]
Masszi, Tamas [1 ]
机构
[1] St Laszlo Hosp, Dept Haematol & Stem Cell Transplantat, H-1097 Budapest, Hungary
[2] State Hlth Ctr, Dept Clin Immunol, Budapest, Hungary
基金
英国医学研究理事会;
关键词
age; beta(2)-microglobulin (beta 2m); immunonephelometry; reference interval; serum; APPROVED RECOMMENDATION 1987; COLLECTED REFERENCE VALUES; STATISTICAL TREATMENT; STAGING SYSTEM; BETA-2-MICROGLOBULIN; PLASMA; ASSAY; BETA2-MICROGLOBULIN; SURVIVAL; RADIOIMMUNOASSAY;
D O I
10.1515/CCLM.2009.137
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Background: Serum beta(2)-microglobulin (beta 2m) has been established as a marker of disease activity in malignancies, autoimmune conditions and infections. Despite its important role in prognosis assessment and disease monitoring, relatively few studies are available on its expression in healthy individuals. Furthermore, interpretation of results is hampered by the variety in reference limits due to differences in methodology, sample population and statistics. Methods: Serum beta 2m concentrations were measured using a microparticle-enhanced immunonephelometric method in 183 healthy blood donors aged 29-75 years. Results: The median beta 2m concentration was 1.67 (0.88-2.75) mg/L with no difference between men and women (1.71 mg/L vs. 1.62 mg/L, p<0.07). A linear correlation was found between beta 2m and age (p<0.0001), serum concentrations significantly higher in older subjects (1.55, 1.59, 1.70, and 1.87 mg/L in age groups of 29-40, 40-50, 50-60 and 60-75 years, respectively, p<0.0001). Reference intervals obtained by non-parametric estimation after partitioning by age were 1.02-2.46 mg/L vs. 1.29-2.70 mg/L in younger (29-49 years) vs. older (50-75 years) individuals. Conclusions: These data can help standardise beta 2m reference limits and support age-adjusted comparisons in clinical studies. Clin Chem Lab Med 2009; 47: 585-9.
引用
收藏
页码:585 / 589
页数:5
相关论文
共 43 条
[1]  
BATAILLE R, 1984, BLOOD, V63, P468
[2]  
BERGGARD I, 1968, J BIOL CHEM, V243, P4095
[3]  
BERNARD AM, 1981, CLIN CHEM, V27, P832
[4]   COMPARISON OF TURBIDIMETRY WITH PARTICLE COUNTING FOR THE DETERMINATION OF HUMAN BETA-2-MICROGLOBULIN BY LATEX IMMUNOASSAY (LIA) [J].
BERNARD, AM ;
LAUWERYS, RR .
CLINICA CHIMICA ACTA, 1982, 119 (03) :335-339
[5]   MEASUREMENT OF BETA-2-MICROGLOBULIN IN SERUM AND PLASMA BY AN ENZYME-LINKED-IMMUNOSORBENT-ASSAY (ELISA) [J].
BJERRUM, OW ;
BIRGENS, HS .
CLINICA CHIMICA ACTA, 1986, 155 (01) :69-76
[6]  
CHILD JA, 1980, CANCER-AM CANCER SOC, V45, P318, DOI 10.1002/1097-0142(19800115)45:2<318::AID-CNCR2820450220>3.0.CO
[7]  
2-C
[8]   IMMUNOLOGICAL IDENTITY OF SMALL SUBUNIT OF HL-A ANTIGENS AND BETA(2)-MICROGLOBULIN AND ITS TURNOVER ON CELL-MEMBRANE [J].
CRESSWEL.P ;
SPRINGER, T ;
STROMING.JL ;
TURNER, MJ ;
GREY, HM ;
KUBO, RT .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1974, 71 (05) :2123-2127
[9]  
CUNNINGHAM BA, 1974, TRANSPLANT REV-DENMA, V21, P3
[10]   FACTORS INFLUENCING SERUM NEOPTERIN AND BETA(2)-MICROGLOBULIN LEVELS IN A HEALTHY DIVERSE POPULATION [J].
DIAMONDSTONE, LS ;
TOLLERUD, DJ ;
FUCHS, D ;
WACHTER, H ;
BROWN, LM ;
MALONEY, E ;
KURMAN, CC ;
NELSON, DL ;
BLATTNER, WA .
JOURNAL OF CLINICAL IMMUNOLOGY, 1994, 14 (06) :368-374