Mesenchymal stromal cells and chronic inflammatory bowel disease

被引：24

作者：

Algeri, M. ^{[1
]}

Conforti, A. ^{[1
]}

Pitisci, A. ^{[1
]}

Starc, N. ^{[1
,3
]}

Tomao, L. ^{[1
]}

Bernardo, M. E. ^{[1
]}

Locatelli, F. ^{[1
,2
]}

机构：

[1] Bambino Gesu Pediat Hosp, Dept Pediat Hematol Oncol, IRCCS, I-00165 Rome, Italy

[2] Univ Pavia, Dept Pediat, I-27100 Pavia, Italy

[3] Univ Roma Tor Vergata, Dept Syst Med, Rome, Italy

来源：

IMMUNOLOGY LETTERS | 2015年 / 168卷 / 02期

关键词：

Mesenchymal stromal cells; Inflammatory bowel disease; Crohn's disease; Ulcerative colitis; Cell therapy; Translational research; Regenerative medicine; COMPLEX PERIANAL FISTULA; REGULATORY T-CELLS; HUMAN BONE-MARROW; STEM-CELLS; CROHNS-DISEASE; EXPERIMENTAL COLITIS; ULCERATIVE-COLITIS; CLINICAL-TRIAL; GRAFT FAILURE; RENAL-FAILURE;

D O I：

10.1016/j.imlet.2015.06.018

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent experimental findings have shown the ability of mesenchymal stromal cells (MSCs) to home to damaged tissues and to produce paracrine factors with anti-inflammatory properties, potentially resulting in reduction of inflammation and functional recovery of the damaged tissues. Prompted by these intriguing properties and on the basis of encouraging preclinical data, MSCs are currently being studied in several immune-mediated disorders. Inflammatory bowel diseases (IBD) represent a setting in which MSCs-based therapy has been extensively investigated. Phase land II studies have documented the safety and feasibility of MSCs. However, efficacy results have so far been conflicting. In this review, we will discuss the biologic rationale that makes MSCs a promising therapeutic tool for IBD, and analyze recent experimental and clinical findings, highlighting current limitations and future perspectives of MSCs-related immunotherapy for IBD. (C) 2015 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：191 / 200

页数：10

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