Risk Factors for Anaplastic Thyroid Cancer

被引：17
|
作者：
Zivaljevic, V. [1 ,2 ]
Slijepcevic, N. [1 ]
Paunovic, I. [1 ,2 ]
Diklic, A. [1 ,2 ]
Kalezic, N. [1 ,2 ]
Marinkovic, J. [2 ,3 ]
Zivic, R. [4 ]
Vekic, B. [4 ]
Sipetic, S. [2 ,5 ]
机构：
[1] Clin Ctr Serbia, Ctr Endocrine Surg, Belgrade 11000, Serbia
[2] Univ Belgrade, Sch Med, Belgrade 11000, Serbia
[3] Univ Belgrade, Sch Med, Inst Med Stat & Informat, Belgrade 11000, Serbia
[4] Clin Ctr Dr Dragisa Misovic, Belgrade 11000, Serbia
[5] Univ Belgrade, Sch Med, Inst Epidemiol, Belgrade 11000, Serbia
来源：
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY | 2014年 / 2014卷
关键词：
BLOOD-TYPE; POOLED ANALYSIS; ENDEMIC GOITER; CARCINOMA; ABO; DISEASE;
D O I：
10.1155/2014/815070
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background. Anaplastic thyroid cancer (ATC) is a form of thyroid cancer with very poor prognosis, but is fortunately quite rare. Its aetiology is unknown and not well researched. Aim. The aim of this study was to identify potential risk factors for ATC. Material and Method. Case-control study of 126 ATC patients (77 females and 49 males) and 252 controls individually matched by gender, age, and place of abode. In statistical analysis we used a Cox regressionmodel. Results. Univariate logistic regression showed that the risk factors for ATC are low education level, type B blood group, goitre, other nonthyroid malignancies, diabetes, late menarche, and an early first pregnancy. Multivariate logistic regression analysis showed that independent risk factors for ATC are low education level (OR = 1.42, 95% CI = 1.09-1.86), type B blood group (OR = 2.41, 95% CI = 1.03-5.66), and goitre (OR = 25-33, 95% CI = 5.66-126.65). Conclusion. Independent risk factors for ATC are: low education level, type B blood group, and goitre.
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页数：6
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