Cannabinoids in Neurologic Illnesses

被引:5
作者
Patel, Anup D. [1 ]
机构
[1] Ohio State Univ, Coll Med, Nationwide Childrens Hosp, Neurol, FOB 41-55,700 Childrens Dr, Columbus, OH 43205 USA
关键词
Marijuana; Cannabinoids; CBD; Cannabidiol; Medical marijuana; Cannabis; Medical cannabis; GUIDELINE DEVELOPMENT SUBCOMMITTEE; MULTIPLE-SCLEROSIS; MEDICAL MARIJUANA; DOUBLE-BLIND; AMERICAN ACADEMY; CANNABIDIOL; SEIZURES; EPILEPSY; SAFETY; PHARMACOLOGY;
D O I
10.1016/j.ncl.2020.09.012
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Marijuana has been used to treat medical disease since well before the 1800s. Recently, increased use of cannabinoids, the chemical components of marijuana, have been seen to treat neurologic illness in children and adults. Unfortunately, data are lacking in treating most neurologic illnesses except in the field of epilepsy and pain from spasticity in multiple sclerosis. Therefore, formal conclusions about the potential efficacy, benefit, and adverse effects for most marijuana based products cannot be made at this time. Further research using gold standard scientific methodology should be performed to help address potential uses and safety for cannabinoids to treat neurologic illnesses. © 2020 Elsevier Inc.
引用
收藏
页码:231 / 241
页数:11
相关论文
共 48 条
  • [1] Alsherbiny Muhammad A, 2018, Medicines (Basel), V6, DOI 10.3390/medicines6010003
  • [2] Labeling Accuracy of Cannabidiol Extracts Sold Online
    Bonn-Miller, Marcel O.
    Loflin, Mallory J. E.
    Thomas, Brian F.
    Marcu, Jahan P.
    Hyke, Travis
    Vandrey, Ryan
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2017, 318 (17): : 1708 - 1709
  • [3] MARIHUANA - THE 1ST 12000 YEARS - ABEL,EL
    BRILL, H
    [J]. JOURNAL OF PSYCHOACTIVE DRUGS, 1981, 13 (04) : 397 - 398
  • [4] Brust J C, 1992, Trans Am Clin Climatol Assoc, V103, P176
  • [5] A double-blind, randomized, placebo-controlled, parallel-group study of Sativex, in subjects with symptoms of spasticity due to multiple sclerosis
    Collin, C.
    Ehler, E.
    Waberzinek, G.
    Alsindi, Z.
    Davies, P.
    Powell, K.
    Notcutt, W.
    O'Leary, C.
    Ratcliffe, S.
    Novakova, I.
    Zapletalova, O.
    Pikova, J.
    Ambler, Z.
    [J]. NEUROLOGICAL RESEARCH, 2010, 32 (05) : 451 - 459
  • [6] Marijuana's Effects on Brain Structure and Function: What Do We Know and What Should We Do? A Brief Review and Commentary
    deShazo, Richard D.
    Parker, Sara B.
    Williams, Daniel
    Ingram, John B.
    Elsohly, Mahmoud
    Rodenmeyer, Kathryn
    McCullouch, Kyle
    [J]. AMERICAN JOURNAL OF MEDICINE, 2019, 132 (03) : 281 - 285
  • [7] Randomized, dose-ranging safety trial of cannabidiol in Dravet syndrome
    Devinsky, Orrin
    Patel, Anup D.
    Thiele, Elizabeth A.
    Wong, Matthew H.
    Appleton, Richard
    Harden, Cynthia L.
    Greenwood, Sam
    Morrison, Gilmour
    Sommerville, Kenneth
    [J]. NEUROLOGY, 2018, 90 (14) : E1204 - +
  • [8] Long-term cannabidiol treatment in patients with Dravet syndrome: An open-label extension trial
    Devinsky, Orrin
    Nabbout, Rima
    Miller, Ian
    Laux, Linda
    Zolnowska, Marta
    Wright, Stephen
    Roberts, Claire
    [J]. EPILEPSIA, 2019, 60 (02) : 294 - 302
  • [9] Effect of Cannabidiol on Drop Seizures in the Lennox-Gastaut Syndrome
    Devinsky, Orrin
    Patel, Anup D.
    Cross, J. Helen
    Villanueva, Vicente
    Wirrell, Elaine C.
    Privitera, Michael
    Greenwood, Sam M.
    Roberts, Claire
    Checketts, Daniel
    VanLandingham, Kevan E.
    Zuberi, Sameer M.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2018, 378 (20) : 1888 - 1897
  • [10] Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome
    Devinsky, Orrin
    Cross, J. Helen
    Laux, Linda
    Marsh, Eric
    Miller, Ian
    Nabbout, Rima
    Scheffer, Ingrid E.
    Thiele, Elizabeth A.
    Wright, Stephen
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2017, 376 (21) : 2011 - 2020