The future of whole-cell modeling

被引：54
作者：
Macklin, Derek N. [1 ]
Ruggero, Nicholas A. [2 ]
Covert, Markus W. [1 ]
机构：
[1] Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA
[2] Stanford Univ, Dept Chem Engn, Stanford, CA 94305 USA
来源：
CURRENT OPINION IN BIOTECHNOLOGY | 2014年 / 28卷
关键词：
ESCHERICHIA-COLI; RNA-SEQ; TRANSCRIPTOME; PROTEOME; TOOL; METABOLISM; NETWORK; GROWTH; GENE;
D O I：
10.1016/j.copbio.2014.01.012
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Integrated whole-cell modeling is poised to make a dramatic impact on molecular and systems biology, bioengineering, and medicine - once certain obstacles are overcome. From our group's experience building a whole-cell model of Mycoplasma genitalium, we identified several significant challenges to building models of more complex cells. Here we review and discuss these challenges in seven areas: first, experimental interrogation; second, data curation; third, model building and integration; fourth, accelerated computation; fifth, analysis and visualization; sixth, model validation; and seventh, collaboration and community development. Surmounting these challenges will require the cooperation of an interdisciplinary group of researchers to create increasingly sophisticated whole-cell models and make data, models, and simulations more accessible to the wider community.
引用
收藏
页码：111 / 115
页数：5
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