Intensity of Free Radical Processes in Rat Liver under Type 2 Diabetes and Introduction of Epifamin

被引：5
作者：
Popova, T. N. [1 ]
Agarkov, A. A. [1 ]
Verevkin, A. N. [1 ]
机构：
[1] Voronezh State Univ, Voronezh 394006, Russia
来源：
ACTA NATURAE | 2013年 / 5卷 / 04期
关键词：
type 2 diabetes mellitus; biochemiluminescence; aconitate hydratase; citrate; caspase; epifamin; OXIDATIVE STRESS; MELATONIN; CELLS;
D O I：
10.32607/20758251-2013-5-4-118-122
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effect of epifamin on free radical processes, the activity of caspase-1 and -3, aconitate hydratase and citrate content in rat's liver at experimentally induced type 2 diabetes mellitus ( T2DM) was studied. The action of epifamin at T2DM leads to a decrease in biochemiluminescence parameters, characterizing the intensity of free radical processes, and changes in aconitase activity and citrate level towards the control. Activities of caspase-1 and caspase-3 in the tissue decreased by a factor of 2.4 and 1.6 in comparison with the levels at the disease. Apparently, epifamin-mediated correction of the level of melatonin, providing a significant antioxidant effect, promotes positive action on the free radical homeostasis.
引用
收藏
页码：118 / 122
页数：5
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