Synthesis, characterization and antiproliferative activity of mixed ligand complexes of Cu2+ and Co2+ with lapachol

被引：4

作者：

Hernandez-Molina, Rita ^{[1
,2
]}

Abramov, Pavel A. ^{[1
,2
,3
]}

Gonzalez-Platas, Javier ^{[4
,5
,6
]}

Oramas-Royo, Sandra ^{[2
,7
]}

Estevez-Braun, Ana ^{[2
,7
]}

Guerra-Rodriguez, Miguel ^{[8
]}

Aranda-Tavio, Haidee ^{[8
]}

Guerra, Borja ^{[8
]}

Fernandez-Perez, Leandro ^{[8
]}

机构：

[1] Univ La Laguna, Dept Quim, Unidad Dept Quim Inorgan, Tenerife 38200, Spain

[2] Inst Univ Biorgan Antonio Gonzalez, Avda Astrofis Francisco Sanchez 2, E-38206 Tenerife, Spain

[3] Nikolaev Inst Inorgan Chem SB RAS, Novosibirsk 630090, Russia

[4] Univ La Laguna, Dept Fis, Avd Astrofis Fco Sanchez S-N, E-38200 Tenerife, Spain

[5] Univ La Laguna, Inst Univ Estudios Avanzados Fis Atom Mol & Foton, Avda Astrofis Fco Sanchez S-N, E-38204 Tenerife, Spain

[6] Univ La Laguna, MALTA Consolider Team, Avda Astrofis Fco Sanchez S-N, E-38204 Tenerife, Spain

[7] Univ La Laguna, Dept Quim Organ, Tenerife, Spain

[8] ULPGC, IUIBS, Lab Farmacol Mol & Traslac, Las Palmas Gran Canaria, Spain

来源：

POLYHEDRON | 2019年 / 165卷

关键词：

Lapachol; Copper; Cobalt; X-ray structures; Biological activity; JAHN-TELLER DISTORTIONS; NAPHTHOQUINONE DERIVATIVES; BETA-LAPACHONE; CRYSTAL; METAL; QUINONES;

D O I：

10.1016/j.poly.2019.03.010

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Mixed ligand complexes [Cu(phen)(Lap)(2)] (1) and [Co(dppeO)(Lap)(2)] (2) were synthesized from the reaction of lapachol (Lap) with [Cu(phen)Cl-2] or [Co(dppe)Cl-2] in the presence of Et3N. Complexes (1) and (2) were fully characterized by X-ray crystallography, elemental analyses, and infrared spectroscopy. Antiproliferative activities of complexes (1) and (2) against several tumor cell lines were also determined alongside those of [Cu(Lap)(2)(EtOH)(2)] (3) and [Co(Lap)(2)(EtOH)(2)] (4). (C) 2019 Elsevier Ltd. All rights reserved.

引用

页码：73 / 78

页数：6

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