High proportion of CD34+/CD38-cells is positively correlated with poor prognosis in newly diagnosed childhood acute lymphoblastic leukemia

被引：12
作者：
Long, Juan [1 ,2 ,3 ,4 ]
Liu, Shan [1 ,2 ,3 ,4 ]
Li, Kang [1 ,2 ,3 ,4 ]
Zhou, Xiaoyan [1 ,2 ,3 ,4 ]
Zhang, Penghui [1 ,2 ,3 ,4 ]
Zou, Lin [1 ,2 ,3 ,4 ]
机构：
[1] Chongqing Med Univ, Ctr Clin Mol Med, Chongqing 400014, Peoples R China
[2] Chongqing Med Univ, Minist Educ, Key Lab Dev Dis, Chongqing 400014, Peoples R China
[3] Chongqing Med Univ, Key Lab Pediat Chongqing, Chongqing 400014, Peoples R China
[4] Chongqing Med Univ, Childrens Hosp, Chongqing Stem Cell Therapy Engn Tech Ctr, Chongqing 400014, Peoples R China
来源：
LEUKEMIA & LYMPHOMA | 2014年 / 55卷 / 03期
关键词：
Percentage of CD34+/CD38-cells; risk stratification; prognosis; childhood acute lymphoblastic leukemia; MINIMAL RESIDUAL DISEASE; ACUTE MYELOID-LEUKEMIA; STEM-CELLS; INITIATING CELLS; CD34; EXPRESSION; FREQUENCY; MICE; CLASSIFICATION; PRECURSOR; CHILDREN;
D O I：
10.3109/10428194.2013.807924
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The CD34+/CD38- immunophenotype is used to identify candidate hematopoietic stem cells (HSCs) and leukemia-initiating cells (LICs). However, the clinical significance of the CD34+/CD38- proportion in childhood acute lymphoblastic leukemia (ALL) is not well established. Here, we found that a high proportion of CD34+/CD38- cells from 112 patients with childhood ALL was negatively correlated with the outcome. Also the percentage of CD34+/CD38- cells was associated with clinical and biological features of patients with ALL. Further, a high proportion of CD34+/CD38- cells in childhood ALL was positively correlated with advanced risk subgroups, which could predict risk stratification by receiver operating characteristic (ROC) curve analysis. In addition, a larger tumor burden and lower survival rate were observed in mice injected with CD34+/CD38- cells, but not in mice injected with other fractions. Our data reveal that a high proportion of CD34+/CD38- cells is positively associated with a poor prognosis of childhood ALL, to further guide therapy of the disease.
引用
收藏
页码：611 / 617
页数：7
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