Active Vision in Marmosets: A Model System for Visual Neuroscience

被引:113
作者
Mitchell, Jude F. [1 ,2 ,3 ]
Reynolds, John H. [1 ]
Miller, Cory T. [2 ,3 ]
机构
[1] Salk Inst Biol Studies, Syst Neurobiol Lab, La Jolla, CA 92037 USA
[2] Univ Calif San Diego, Dept Psychol, La Jolla, CA 92093 USA
[3] Univ Calif San Diego, Grad Program Neurosci, La Jolla, CA 92093 USA
关键词
behavioral conditioning; eye movements; marmoset; primate; saccades; vision; NEW-WORLD MONKEY; LATERAL GENICULATE-NUCLEUS; PRIMATE AUDITORY-CORTEX; CALLITHRIX-JACCHUS; COMMON MARMOSETS; CORTICAL AREAS; EYE-MOVEMENTS; NONHUMAN PRIMATE; MACAQUE MONKEYS; CEREBRAL-CORTEX;
D O I
10.1523/JNEUROSCI.3899-13.2014
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The common marmoset (Callithrix jacchus), a small-bodied New World primate, offers several advantages to complement vision research in larger primates. Studies in the anesthetized marmoset have detailed the anatomy and physiology of their visual system (Rosa et al., 2009) while studies of auditory and vocal processing have established their utility for awake and behaving neurophysiological investigations (Lu et al., 2001a, b; Eliades and Wang, 2008a, b; Osmanski and Wang, 2011; Remington et al., 2012). However, a critical unknown is whether marmosets can perform visual tasks under head restraint. This has been essential for studies in macaques, enabling both accurate eye tracking and head stabilization for neurophysiology. In one set of experiments we compared the free viewing behavior of head-fixed marmosets to that of macaques, and found that their saccadic behavior is comparable across a number of saccade metrics and that saccades target similar regions of interest including faces. In a second set of experiments we applied behavioral conditioning techniques to determine whether the marmoset could control fixation for liquid reward. Two marmosets could fixate a central point and ignore peripheral flashing stimuli, as needed for receptive field mapping. Both marmosets also performed an orientation discrimination task, exhibiting a saturating psychometric function with reliable performance and shorter reaction times for easier discriminations. These data suggest that the marmoset is a viable model for studies of active vision and its underlying neural mechanisms.
引用
收藏
页码:1183 / 1194
页数:12
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