Does intravenous saline infusion compromise the stability of [123I] meta-iodobenzylguanidine?

被引：1

作者：

Martinez, Teresa ^{[1
]}

Chivato, Tomas ^{[2
]}

Roldan, Marta ^{[2
]}

Minana, Elena ^{[2
]}

机构：

[1] Santa Lucias Hosp, Radiopharm Unit, Cartagena, Spain

[2] Virgen de la Arrixaca Hosp, Radiopharm Unit, Murcia, Spain

来源：

NUCLEAR MEDICINE COMMUNICATIONS | 2014年 / 35卷 / 06期

关键词：

sodium chloride; 123I] iodine; stability; 123I] meta-iodobenzylguanidine; adverse reactions; infusion; RADIOCHEMICAL PURITY; I-131-LABELED METAIODOBENZYLGUANIDINE; ADVERSE-REACTIONS; RADIOPHARMACEUTICALS; FLUIDS;

D O I：

10.1097/MNM.0000000000000103

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

To avoid adverse effects during the administration of [I-123] meta-iodobenzylguanidine (MIBG), infusion of the drug that has been previously diluted is proposed. Stability of [I-123] MIBG in sodium chloride solutions is studied, looking for incompatibilities in the formulation. Stability was tested on the basis of the percentage of free [I-123] iodide on solid-phase extraction. No increase in percentages of free [I-123] iodide was found in diluted and undiluted samples over time (P > 0.05). Intravenous saline infusion of [I-123] MIBG could be a useful tool for controlling the administration rate, minimizing the side effects and lowering the exposure of the staff to ionizing radiation.

引用

页码：683 / 685

页数：3

共 15 条

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