Artesunate plus sulfadoxine-pyrimethamine in the treatment of uncomplicated Plasmodium falciparum malaria during pregnancy in eastern Sudan

被引:34
作者
Adam, Ishag
Ali, Daw M.
Abdalla, Mohammed A.
机构
[1] Univ Khartoum, Fac Med, Dept Obstet & Gynecol, Khartoum, Sudan
[2] New Halfa Teaching Hosp, New Halfa, Sudan
[3] Acad Med Sci & Technol, Khartoum, Sudan
关键词
Plasmodium falciparum; pregnancy; artesunate; sulfadoxine-pyrimethamine; Sudan;
D O I
10.1016/j.trstmh.2005.09.019
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Malaria during pregnancy is associated with serious adverse effects; these could be avoided with effective treatment. Artesunate plus sulfadoxine-pyrimethamine (AS+SP) is a promising antimalarial combination; however, few data are available on its safety during pregnancy. The present study was carried out in New Halfa Hospital., eastern Sudan, between September 2004 and March 2005. Thirty-two pregnant Sudanese women with uncomplicated Plasmodium falciparum malaria were treated with AS + SP at a mean of 29.7 weeks of gestation. The patients were followed-up until delivery and the babies were followed-up until the age of 1 month. The drug was well tolerated, the parasitaemia was cleared and the patients were symptom-free within 2 days. All the patients delivered full-term live babies. One of the babies died on the fourth day; none of the women died and there was no miscarriage, stillbirth, or congenital abnormalities in the newborn babies. Thus, this small descriptive study failed to detect unintended effects of AS+SP during pregnancy. (C) 2005 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:632 / 635
页数:4
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