Chitosan cross-linked with poly(ethylene glycol)dialdehyde via reductive amination as effective controlled release carriers for oral protein drug delivery

被引:39
作者
Jing, Zi-Wei [1 ]
Ma, Zhi-Wei [2 ]
Li, Chen [1 ]
Jia, Yi-Yang [1 ]
Luo, Min [1 ]
Ma, Xi-Xi [1 ]
Zhou, Si-Yuan [1 ]
Zhang, Bang-Le [1 ]
机构
[1] Fourth Mil Med Univ, Sch Pharm, Dept Pharmaceut, Xian 710032, Peoples R China
[2] Fourth Mil Med Univ, Qindu Hosp, Xian 710032, Peoples R China
基金
中国国家自然科学基金;
关键词
Chitosan; Poly(ethylene glycol); Crosslinking; Hydrogel; Controlled delivery system; HYDROGELS; NANOPARTICLES; DESIGN; ACIDS;
D O I
10.1016/j.bmcl.2016.12.072
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The covalently cross-linked chitosan-poly(ethylene glycol)1540 derivatives have been developed as a controlled release system with potential for the delivery of protein drug. The swelling characteristics of the hydrogels based on these derivatives as the function of different PEG content and the release profiles of a model protein (bovine serum albumin, BSA) from the hydrogels were evaluated in simulated gastric fluid with or without enzyme in order to simulate the gastrointestinal tract conditions. The derivatives cross linked with difunctional PEG(1540)-dialdehyde via reductive amination can swell in alkaline pH and remain insoluble in acidic medium. The cumulative release amount of BSA was relatively low in the initial 2 h and increased significantly at pH 7.4 with intestinal lysozyme for additional 12 h. The results proved that the release-and-hold behavior of the cross-linked CS-PEG(1540)H-CS hydrogel provided a swell and intestinal enzyme controlled release carrier system, which is suitable for oral protein drug delivery. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1003 / 1006
页数:4
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