L-proline-catalyzed one-pot three-component reaction for the synthesis of β-alkoxy ketones

被引：18

作者：

Dodda, Rajasekhar ^{[1
]}

Zhao, Cong-Gui ^{[1
]}

机构：

[1] Univ Texas, Dept Chem, San Antonio, TX 78249 USA

来源：

SYNTHESIS-STUTTGART | 2006年 / 19卷 / 19期

关键词：

beta-alkoxy ketones; aldehydes; alcohols; one-pot reaction; aldol reactions; Mannich addition;

D O I：

10.1055/s-2006-950184

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

beta-Alkoxy ketones were prepared by a one-pot three-component reaction of aliphatic aldehydes, ketones, and alcohols catalyzed by L-proline. Steric effects on the reaction were studied with substituted ketones, aldehydes, and alcohols, and the results indicate that reactions employing methyl ketones, alpha-unsubstituted aliphatic aldehydes and methanol produce the beta-alkoxy ketones in the best yields when L-proline is used as the catalyst. The reaction mechanism is discussed.

引用

页码：3238 / 3242

页数：5

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