Heart Xenotransplantation: Historical Background, Experimental Progress, and Clinical Prospects

被引：27

作者：

Murthy, Raghav

Bajona, Pietro ^{[1
]}

Bhama, Jay K.

Cooper, David K. C.

机构：

[1] Univ Texas SW Med Ctr Dallas, Div Thorac & Cardiovasc Surg, 5959 Harry Hines Blvd,Ste HP10-110, Dallas, TX 75390 USA

来源：

ANNALS OF THORACIC SURGERY | 2016年 / 101卷 / 04期

基金：

美国国家卫生研究院;

关键词：

CARDIAC XENOGRAFT SURVIVAL; HYPERACUTE REJECTION; NONHUMAN-PRIMATES; TRANSGENIC PIGS; KNOCKOUT PIGS; TRANSPLANTATION; EXPRESSION; ANTIBODIES; EXPERIENCE; DONORS;

D O I：

10.1016/j.athoracsur.2015.10.017

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

If pig hearts could be transplanted successfully into patients with end-stage cardiac failure, the critical shortage of hearts from deceased human donors would be overcome. The several attempts at cardiac xenotransplantation carried out in the 20th century, usually with hearts from nonhuman primates (NHPs), are reviewed, as are the surgical techniques used in experimental heart transplantation in animals. For a number of reasons, the pig has been selected as the potential source of organs for clinical transplantation. The major pathobiological barriers that the pig presents, and progress in overcoming these barriers either by genetic engineering of the pig or by the administration of novel immunosuppressive agents, are described. Currently, non life-supporting pig heterotopic heart transplantation in NHPs has extended to more than 2 years in 1 case, with life-supporting orthotopic heart transplantation of almost 2 months. Future approaches to resolve the remaining problems and the selection of patients for the initial clinical trials are briefly discussed. (C) 2016 by The Society of Thoracic Surgeons

引用

页码：1605 / 1613

页数：9

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