Mild, one-pot preparation of 2-substituted benzimidazoles from organic halides

被引：3

作者：

Bratulescu, George ^{[1
]}

机构：

[1] Univ Craiova, Dept Chem, 13 AI Cuza, Craiova 200585, Romania

来源：

SYNTHETIC COMMUNICATIONS | 2017年 / 47卷 / 08期

关键词：

Benzimidazoles; domino reaction; dry medium; oxidation; MICROWAVE IRRADIATION; CATALYZED SYNTHESIS; BOND FORMATION; DERIVATIVES; EFFICIENT; 2-ARYLBENZIMIDAZOLES; HETEROCYCLES; INHIBITORS; BROMIDES; DIOXIDE;

D O I：

10.1080/00397911.2017.1287922

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Alkyl halides are feasibly transformed into benzimidazoles by a domino reaction under solvent-free conditions. The organic halides react with o-phenylenediamines in stoichiometric amounts in the presence of pyridine-N-oxide to produce the desired substituted benzimidazoles. This domino synthesis does not require catalysts. The synthesis occurs in dry medium and the environmental impact is minimal. The method provides products without intermediate separation. A mechanism of benzimidazole synthesis is also proposed.

引用

页码：811 / 817

页数：7

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