Histone modifications in oral squamous cell carcinoma and oral potentially malignant disorders

被引：21
作者：
Yang, Huamei [1 ]
Jin, Xin [2 ,3 ]
Dan, Hongxia [1 ]
Chen, Qianming [1 ]
机构：
[1] Sichuan Univ, Chinese Acad Med Sci,West China Hosp Stomatol, Res Unit Oral Med Carcinogenesis & Management, State Key Lab Oral Dis,Natl Clin Res Ctr Oral Dis, Chengdu, Sichuan, Peoples R China
[2] Chongqing Med Univ, Coll Stomatol, Chongqing, Peoples R China
[3] Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing, Peoples R China
来源：
ORAL DISEASES | 2020年 / 26卷 / 04期
关键词：
histone modifications; histone-modifying enzymes; inhibitors; malignant transformation; oral potentially malignant disorders; oral squamous cell carcinoma; SUBEROYLANILIDE HYDROXAMIC ACID; DEACETYLASE INHIBITOR FR901228; AURORA-B EXPRESSION; PHASE-II TRIAL; THERAPEUTIC TARGET; HDAC INHIBITOR; INTRAEPITHELIAL NEOPLASIA; SPECIFICITY PROTEIN-1; EPIGENETIC MECHANISMS; EPITHELIAL DYSPLASIA;
D O I：
10.1111/odi.13115
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
Oral squamous cell carcinoma (OSCC) is a common malignancy with dismal prognosis without effective therapeutic options in advanced cases. The evolution from oral potentially malignant disorders to OSCC has poorly described underlying epigenetic features. With the ability of silencing or activation of vital genes, histone modifications' and modifiers' potentiality for early diagnosis, prognosis predicting, and therapy in OSCC were evaluated by extensive epigenetic studies. This review investigates the roles of dysregulated histone modifications and the associated modifying enzymes in OSCC onset and progression. Also, we focus on the current advances of histone modifications as therapeutic targets and the potential value of epi-drugs.
引用
收藏
页码：719 / 732
页数：14
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