Prognostic factors of patients who received chemotherapy after cranial irradiation for non-small cell lung cancer with brain metastases: A retrospective analysis of multicenter study (Anatolian Society of Medical Oncology)

被引：5

作者：

Inal, Ali ^{[1
]}

Kodaz, Hilmi ^{[3
]}

Odabas, Hatice ^{[4
]}

Duran, Ayse Ocak ^{[10
]}

Seker, Mehmet Metin ^{[12
]}

Inanc, Mevlide ^{[11
]}

Elkiran, Emin Tamer ^{[13
]}

Gunaydin, Yusuf ^{[14
]}

Menekse, Serkan ^{[17
]}

Topcu, Turkan Ozturk ^{[18
]}

Urakci, Zuhat ^{[19
]}

Tastekin, Didem ^{[5
]}

Bilici, Mehmet ^{[20
]}

Cihan, Sener ^{[6
]}

Geredeli, Caglayan ^{[21
]}

Sezer, Emel ^{[2
]}

Uncu, Dogan ^{[15
]}

Arpaci, Erkan ^{[22
]}

Ozturk, Banu ^{[23
]}

Bal, Oznur ^{[16
]}

Uysal, Mukremin ^{[24
]}

Tanriverdi, Ozgur ^{[25
]}

Gumus, Mahmut ^{[7
]}

Ustaalioglu, Bala Basak Oven ^{[8
]}

Suner, Ali ^{[26
]}

Cokmert, Suna ^{[9
]}

Hacibekiroglu, Ilhan ^{[3
]}

Aydin, Kubra ^{[4
]}

Isikdogan, Abdurrahman ^{[19
]}

机构：

[1] Mersin Hosp, Dept Med Oncol, Mersin, Turkey

[2] Mersin Univ, Dept Med Oncol, Mersin, Turkey

[3] Trakya Univ, Dept Med Oncol, Edirne, Turkey

[4] Dr Lutfi Kirdar Kartal Educ & Res Hosp, Dept Med Oncol, Istanbul, Turkey

[5] Istanbul Univ, Dept Med Oncol, Istanbul, Turkey

[6] Istanbul Univ, Okmeydani Educ & Res Hosp, Dept Med Oncol, Istanbul, Turkey

[7] Bezmialem Vakif Univ, Dept Med Oncol, Istanbul, Turkey

[8] Haydarpasa Numune Educ & Res Hosp, Dept Med Oncol, Istanbul, Turkey

[9] Kent Hosp, Dept Med Oncol, Istanbul, Turkey

[10] Erciyes Univ, Dept Med Oncol, Kayseri, Turkey

[11] Kayseri Numune Educ & Res Hosp, Dept Med Oncol, Kayseri, Turkey

[12] Cumhuriyet Univ, Dept Med Oncol, Sivas, Turkey

[13] Inonu Univ, Dept Med Oncol, Malatya, Turkey

[14] Gazi Univ, Dept Med Oncol, Ankara, Turkey

[15] Ankara Numune Training & Res Hosp, Dept Med Oncol, Manisa, Turkey

[16] Ankara Onkol Educ & Res Hosp, Dept Med Oncol, Manisa, Turkey

[17] Celal Bayar Univ, Dept Med Oncol, Manisa, Turkey

[18] Karadeniz Tech Univ, Dept Med Oncol, Trabzon, Turkey

[19] Dicle Univ, Dept Med Oncol, Diyarbakir, Turkey

[20] Ataturk Univ, Dept Med Oncol, Erzurum, Turkey

[21] Konya Numune Hosp, Dept Med Oncol, Konya, Turkey

[22] Sakarya Univ, Dept Med Oncol, Sakarya, Turkey

[23] Gaziosmanpasa Univ, Dept Med Oncol, Yozgat, Turkey

[24] Afyon Kocatepe Univ, Dept Med Oncol, Afyon, Turkey

[25] Mugla Sitki Kocman Univ, Dept Med Oncol, Mugla, Turkey

[26] Gaziantep Univ, Dept Med Oncol, Gaziantep, Turkey

来源：

JOURNAL OF CANCER RESEARCH AND THERAPEUTICS | 2018年 / 14卷 / 03期

关键词：

Brain metastases; non-small cell lung cancer; prognostic factors; TYROSINE KINASE INHIBITORS; PHASE-II-TRIAL; RADICAL TREATMENT; NEVER-SMOKERS; SURVIVAL; ADENOCARCINOMA; MANAGEMENT; THERAPY; RADIOTHERAPY; GEFITINIB;

D O I：

10.4103/0973-1482.176417

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose: Almost half of all patients diagnosed with non-small cell lung cancer (NSCLC) have distant metastases at presentation. One-third of patients with NSCLC will have brain metastases. Without effective treatment, the median survival is only 1 month. However, it is difficult to treat brain metastases with systemic chemotherapy since the agents have difficulty crossing the blood-brain barrier. Therefore, it is important to estimate the patient's survival prognosis. The aim of this study was to analyze prognostic factors for survival in Turkish patients who received chemotherapy after cranial irradiation for NSCLC with brain metastases. Methods: We retrospectively reviewed 698 patients with brain metastases resulting from NSCLC. Ten potential prognostic variables were chosen for analysis. Univariate and multivariate analyses were conducted to identify prognostic factors associated with overall survival (OS). Results: Among the 10 variables for univariate analysis, six were identified to have prognostic significance; these included sex, smoking history, histology, number of brain metastases, extracranial metastases, and neurosurgical resection. Multivariate analysis by the Cox proportional hazard model showed that a smoking history, extracranial metastases, and neurosurgical resection were independent negative prognostic factors for OS. Conclusion: Smoking history, extracranial metastases, and neurosurgical resection were considered independent negative prognostic factors for OS. These findings may facilitate pretreatment prediction of survival and can be used for selecting patients for more appropriate treatment options.

引用

页码：578 / 582

页数：5

共 26 条

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