The use of biomarkers in Alzheimer's disease: a case report

被引:1
作者
Stanley, Karen [1 ]
Stevens, Tim [1 ]
Walker, Zuzana [1 ,2 ]
机构
[1] EPUT Essex Partnership Univ NHS Fdn Trust, St Margarets Hosp, Runwell, Wickford, England
[2] UCL, Elderly Psychiat, Div Psychiat, London, England
关键词
MILD COGNITIVE IMPAIRMENT; AMYLOID DEPOSITION; CHALLENGES; DISCLOSURE; DIAGNOSIS; DEMENTIA; DECLINE; PET;
D O I
10.1002/pnp.540
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Uncertainties remain around the use of biomarkers in clinical practice to diagnose Alzheime's disease. There are several implications for both patients and clinicians, including the ethical and practical dilemmas of identifying a disease process early in its course when there are no disease-modifying treatments available.
引用
收藏
页码:10 / 14
页数:5
相关论文
共 23 条
[1]   Relationship between Atrophy and β-Amyloid Deposition in Alzheimer Disease [J].
Chetelat, Gael ;
Villemagne, Victor L. ;
Bourgeat, Pierrick ;
Pike, Kerryn E. ;
Jones, Gareth ;
Ames, David ;
Ellis, Kathryn A. ;
Szoeke, Cassandra ;
Martins, Ralph N. ;
O'Keefe, Graeme J. ;
Salvado, Olivier ;
Masters, Colin L. ;
Rowe, Christopher C. .
ANNALS OF NEUROLOGY, 2010, 67 (03) :317-324
[2]   Alzheimer's disease diagnostic criteria: practical applications [J].
Cummings, Jeffrey .
ALZHEIMERS RESEARCH & THERAPY, 2012, 4 (05)
[3]   Alzheimer disease and pre-emptive suicide [J].
Davis, Dena S. .
JOURNAL OF MEDICAL ETHICS, 2014, 40 (08) :543-549
[4]   Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria [J].
Dubois, Bruno ;
Hampel, Harald ;
Feldman, Howard H. ;
Scheltens, Philip ;
Aisen, Paul ;
Andrieu, Sandrine ;
Bakardjian, Hovagim ;
Benali, Habib ;
Bertram, Lars ;
Blennow, Kaj ;
Broich, Karl ;
Cavedo, Enrica ;
Crutch, Sebastian ;
Dartigues, Jean-Francois ;
Duyckaerts, Charles ;
Epelbaum, Stephane ;
Frisoni, Giovanni B. ;
Gauthier, Serge ;
Genthon, Remy ;
Gouw, Alida A. ;
Habert, Marie-Odile ;
Holtzman, David M. ;
Kivipelto, Miia ;
Lista, Simone ;
Molinuevo, Jose-Luis ;
O'Bryant, Sid E. ;
Rabinovici, Gil D. ;
Rowe, Christopher ;
Salloway, Stephen ;
Schneider, Lon S. ;
Sperling, Reisa ;
Teichmann, Marc ;
Carrillo, Maria C. ;
Cummings, Jeffrey ;
Jack, Cliff R., Jr. .
ALZHEIMERS & DEMENTIA, 2016, 12 (03) :292-323
[5]   Development of a process to disclose amyloid imaging results to cognitively normal older adult research participants [J].
Harkins, Kristin ;
Sankar, Pamela ;
Sperling, Reisa ;
Grill, Joshua D. ;
Green, Robert C. ;
Johnson, Keith A. ;
Healy, Megan ;
Karlawish, Jason .
ALZHEIMERS RESEARCH & THERAPY, 2015, 7
[6]  
Johnson KA, 2013, ALZHEIMERS DEMENT, V9, pE1, DOI [10.1016/j.jalz.2013.01.002, 10.1016/j.jalz.2012.10.007, 10.1016/j.jalz.2013.06.001]
[7]   Brain Imaging in Alzheimer Disease [J].
Johnson, Keith A. ;
Fox, Nick C. ;
Sperling, Reisa A. ;
Klunk, William E. .
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2012, 2 (04)
[8]   Addressing the ethical, policy, and social challenges of preclinical Alzheimer disease [J].
Karlawish, Jason .
NEUROLOGY, 2011, 77 (15) :1487-1493
[9]   Practice parameter: Diagnosis of dementia (an evidence-based review) - Report of the Quality Standards Subcommittee of the American Academy of Neurology [J].
Knopman, DS ;
DeKosky, ST ;
Cummings, JL ;
Chui, H ;
Corey-Bloom, J ;
Relkin, N ;
Small, GW ;
Miller, B ;
Stevens, JC .
NEUROLOGY, 2001, 56 (09) :1143-1153
[10]   The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease [J].
McKhann, Guy M. ;
Knopman, David S. ;
Chertkow, Howard ;
Hyman, Bradley T. ;
Jack, Clifford R., Jr. ;
Kawas, Claudia H. ;
Klunk, William E. ;
Koroshetz, Walter J. ;
Manly, Jennifer J. ;
Mayeux, Richard ;
Mohs, Richard C. ;
Morris, John C. ;
Rossor, Martin N. ;
Scheltens, Philip ;
Carrillo, Maria C. ;
Thies, Bill ;
Weintraub, Sandra ;
Phelps, Creighton H. .
ALZHEIMERS & DEMENTIA, 2011, 7 (03) :263-269