Prospects for Life Span Extension

被引：59

作者：

Sierra, Felipe ^{[1
]}

Hadley, Evan ^{[1
]}

Suzman, Richard ^{[1
]}

Hodes, Richard ^{[1
]}

机构：

[1] NIA, NIH, Bethesda, MD 20892 USA

来源：

ANNUAL REVIEW OF MEDICINE | 2009年 / 60卷

关键词：

aging; longevity; CALORIC RESTRICTION; GROWTH-HORMONE; OXIDATIVE STRESS; CAENORHABDITIS-ELEGANS; UNITED-STATES; RISK-FACTORS; LONGEVITY; INSULIN; MORTALITY; SIRTUINS;

D O I：

10.1146/annurev.med.60.061607.220533

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Life expectancy has increased dramatically in the United States and in much of the world in recent years and decades. The factors underlying this increase are incompletely understood and are undoubtedly complex. A question that drives current research is whether life expectancy call he further extended using current knowledge of modifiable risk factors. A still more challenging research focus is on the possibility that life expectancy might he further increased through knowledge gained from studies of the basic biology of aging and its genetic and environmental modifiers.

引用

页码：457 / 469

页数：13

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