Therapeutic Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on Neuroinflammation and Neuroplasticity in Patients with Parkinson's Disease: a Placebo-Controlled Study

被引：36

作者：

Aftanas, L. I. ^{[1
,2
]}

Gevorgyan, M. M. ^{[1
]}

Zhanaeva, S. Ya. ^{[1
]}

Dzemidovich, S. S. ^{[1
]}

Kulikova, K. I. ^{[1
]}

Al'perina, E. L. ^{[1
]}

Danilenko, K. V. ^{[1
,2
]}

Idova, G. V. ^{[1
,2
]}

机构：

[1] Res Inst Physiol & Fundamental Med, Novosibirsk, Russia

[2] Novosibirsk Natl Res State Univ, Novosibirsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2018年 / 165卷 / 02期

基金：

俄罗斯基础研究基金会;

关键词：

Parkinson's disease; high-frequency repetitive transcranial magnetic stimulation (rTMS); pro- and anti-inflammatory cytokines; BDNF; MECHANISMS; DOPAMINE; MOTOR; RAT;

D O I：

10.1007/s10517-018-4128-4

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The parallel placebo-controlled study examined the therapeutic effects of dual-target repetitive transcranial magnetic stimulation (rTMS) of the motor cortex (bilaterally) and the left prefrontal cortex (dorsolaterally) on spontaneous and mitogen-stimulating synthesis of pro- and anti-inflammatory cytokines by the blood cells and the level of brain-derived neurotrophic factor (BDNF) in blood serum of patients with Parkinson's disease. The significantly steeper positive clinical dynamics (assessed by UPRSD scale) observed in rTMS group in comparison with the placebo group was accompanied by a significant drop in spontaneous production of proinflammatory cytokines IFN gamma and IL-17A. rTMS produced no significant effect on serum BDNF. The possible mechanisms of rTMS therapeutic action on the level of cytokines associated with neuroinflammation in patients with Parkinson's disease are discussed.

引用

页码：195 / 199

页数：5

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