Easily Accessible Auxiliary for Palladium-Catalyzed Intramolecular Amination of C(sp2)-H and C(sp3)-H Bonds at δ- and ε-Positions

被引：142

作者：

Wang, Chao ^{[1
]}

Chen, Changpeng ^{[1
]}

Zhang, Jingyu ^{[1
]}

Han, Jian ^{[1
]}

Wang, Qian ^{[1
]}

Guo, Kun ^{[1
]}

Liu, Pei ^{[1
]}

Guan, Mingyu ^{[1
]}

Yao, Yingming ^{[1
]}

Zhao, Yingsheng ^{[1
]}

机构：

[1] Soochow Univ, Key Lab Organ Synth Jiangsu Prov, Jiangsu Prov Coll Chem, Coll Chem Chem Engn & Mat Sci, Suzhou 215123, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2014年 / 53卷 / 37期

关键词：

amination; CH activation; cyclization; heterocycles; palladium; C-H BONDS; DIRECTING GROUP; ACTIVATION; ARYLATION; FUNCTIONALIZATION; ALKYLATION; INDOLINES; CONSTRUCTION; DERIVATIVES; SELECTIVITY;

D O I：

10.1002/anie.201404854

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An easily synthesized and accessible N,O-bidentate auxiliary has been developed for selective CH activation under palladium catalysis. The novel auxiliary showed its first powerful application in CH functionalization of remote positions. Both C(sp(2))H and C(sp(3))H bonds at - and epsilon-positions were effectively activated, thus giving tetrahydroquinolines, benzomorpholines, pyrrolidines, and indolines in moderate to excellent yields by palladium-catalyzed intramolecular CH amination.

引用

页码：9884 / 9888

页数：5

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