Population-based seroprevalence of SARS-CoV-2 and the herd immunity threshold in Maranhao

被引：30

作者：

Moura da Silva, Antonio Augusto ^{[1
]}

Goncalves Lima-Neto, Lidio ^{[2
,3
]}

Pedrozo e Silva de Azevedo, Conceicao de Maria ^{[4
,5
]}

Melo da Costa, Lea Marcia ^{[6
]}

Barbosa Martins Braganca, Maylla Luana ^{[7
]}

Barros Filho, Allan Kardec Duailibe ^{[8
]}

Wittlin, Bernardo Bastos ^{[5
,9
]}

de Souza, Bruno Feres ^{[10
]}

Alves de Oliveira, Bruno Luciano Carneiro ^{[4
]}

de Carvalho, Carolina Abreu ^{[11
]}

Abreu Fonseca Thomaz, Erika Barbara ^{[1
]}

Simoes-Neto, Eudes Alves ^{[9
,12
]}

Leite Junior, Jamesson Ferreira ^{[13
]}

Sousa Santos Cosme, Lecia Maria ^{[2
]}

Garcia Campos, Marcos Adriano ^{[14
]}

de Sousa Queiroz, Rejane Christine ^{[1
]}

Costa, Sergio Souza ^{[10
]}

de Carvalho, Vitoria Abreu ^{[14
]}

Ferreira Simoes, Vanda Maria ^{[1
]}

de Britt e Alves, Maria Teresa Seabra Soares ^{[1
]}

dos Santos, Alcione Miranda ^{[1
]}

机构：

[1] Univ Fed Maranhao, Dept Saude Publ, Rua Barao Itapary 155, BR-65020070 Sao Luis, Maranhao, Brazil

[2] Secretaria Saude Estado Maranhao, Lab Cent Maranhao, Sao Luis, Maranhao, Brazil

[3] Univ CEUMA, Sao Luis, Maranhao, Brazil

[4] Univ Fed Maranhao, Dept Med 1, Sao Luis, Maranhao, Brazil

[5] Hosp Presidente Vargas, Secretaria Saude Estado Maranhao, Sao Luis, Maranhao, Brazil

[6] Secretaria Saude Estado Maranhao, Sao Luis, Maranhao, Brazil

[7] Univ Fed Maranhao, Dept Ciencias Fisiol, Sao Luis, Maranhao, Brazil

[8] Univ Fed Maranhao, Dept Engn Eletr, Sao Luis, Maranhao, Brazil

[9] Univ Fed Maranhao, Hosp Univ, Sao Luis, Maranhao, Brazil

[10] Univ Fed Maranhao, Dept Engn Comp, Sao Luis, Maranhao, Brazil

[11] Univ Fed Maranhao, Curso Med, Pinheiro, MA, Brazil

[12] Secretaria Municipal Saude, Sao Luis, Maranhao, Brazil

[13] Ctr Informacoes Estrateg Vigilancia Saude, Secretaria Saude Estado Maranhao, Sao Luis, Maranhao, Brazil

[14] Univ Fed Maranhao, Programa Posgrad Saude Colet, Sao Luis, Maranhao, Brazil

来源：

REVISTA DE SAUDE PUBLICA | 2020年 / 54卷

关键词：

Seroepidemiologic Studies; Coronavirus Infections; Immunity; Herd; Mortality;

D O I：

10.11606/s1518-8787.2020054003278

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

OBJECTIVE: To estimate the seroprevalence of SARS-CoV-2 in the state of Maranhao, Brazil. METHODS: A population-based household survey was performed, from July 27, 2020 to August 8, 2020. The estimates considered clustering, stratification and non-response. Qualitative detection of IgM and IgG antibodies was performed in a fully-automated Elecsys (R) Anti-SARS-CoV-2 electrochemiluminescence immunoassay on the Cobas (R) e601 analyzer (Roche Diagnostics). RESULTS: In total, 3,156 individuals were interviewed. Seroprevalence of total antibodies against SARS-CoV-2 was 40.4% (95%CI 35.6-45.3). Population adherence to non-pharmaceutical interventions was higher at the beginning of the pandemic than in the last month. SARS-CoV-2 infection rates were significantly lower among mask wearers and among those who maintained social and physical distancing in the last month compared to their counterparts. Among the infected, 26.0% were asymptomatic. The infection fatality rate (IFR) was 0.14%, higher for men and older adults. The IFR based on excess deaths was 0.28%. The ratio of estimated infections to reported cases was 22.2. CONCLUSIONS: To the best of our knowledge, the seroprevalence of SARS-CoV-2 estimated in this population-based survey is one of the highest reported. The local herd immunity threshold may have been reached or might be reached soon.

引用

页码：1 / 14

页数：14

共 43 条

[1]

Aguas R., 2020, medRxiv, DOI DOI 10.1101/2020.07.23.20160762

[2] Diagnostic accuracy of serological tests for covid-19: systematic review and meta-analysis [J].

Bastos, Mayara Lisboa ;

Tavaziva, Gamuchirai ;

Abidi, Syed Kunal ;

Campbell, Jonathon R. ;

Haraoui, Louis -Patrick ;

Johnston, James C. ;

Lan, Zhiyi ;

Law, Stephanie ;

MacLean, Emily ;

Trajman, Anete ;

Menzies, Dick ;

Benedetti, Andrea ;

Khan, Faiz Ahmad .

BMJ-BRITISH MEDICAL JOURNAL, 2020, 370

[3] A mathematical model reveals the influence of population heterogeneity on herd immunity to SARS-CoV-2 [J].

Britton, Tom ;

Ball, Frank ;

Trapman, Pieter .

SCIENCE, 2020, 369 (6505) :846-+

[4]

Buss LF, 2020, Nat Aging, DOI [10.1101/2020.09.16.20194787, DOI 10.1101/2020.09.16.20194787]

[5]

Byambasuren Oyungerel, 2020, J Assoc Med Microbiol Infect Dis Can, V5, P223, DOI 10.3138/jammi-2020-0030

[6] Physical distancing, face masks, and eye protection to prevent person-to-person transmission of SARS-CoV-2 and COVID-19: a systematic review and meta-analysis [J].

Chu, Derek K. ;

Akl, Elie A. ;

Duda, Stephanie ;

Solo, Karla ;

Yaacoub, Sally ;

Schunemann, Holger J. .

LANCET, 2020, 395 (10242) :1973-1987

[7]

Conselho Nacional de Secretarios de Saude, 2020, PAIN AN EXC MORT CAU

[8] Estimating the effects of non-pharmaceutical interventions on COVID-19 in Europe [J].

Flaxman, Seth ;

Mishra, Swapnil ;

Gandy, Axel ;

Unwin, H. Juliette T. ;

Mellan, Thomas A. ;

Coupland, Helen ;

Whittaker, Charles ;

Zhu, Harrison ;

Berah, Tresnia ;

Eaton, Jeffrey W. ;

Monod, Melodie ;

Ghani, Azra C. ;

Donnelly, Christl A. ;

Riley, Steven ;

Vollmer, Michaela A. C. ;

Ferguson, Neil M. ;

Okell, Lucy C. ;

Bhatt, Samir .

NATURE, 2020, 584 (7820) :257-+

[9] Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals [J].

Grifoni, Alba ;

Weiskopf, Daniela ;

Ramirez, Sydney, I ;

Mateus, Jose ;

Dan, Jennifer M. ;

Moderbacher, Carolyn Rydyznski ;

Rawlings, Stephen A. ;

Sutherland, Aaron ;

Premkumar, Lakshmanane ;

Jadi, Ramesh S. ;

Marrama, Daniel ;

de Silva, Aravinda M. ;

Frazier, April ;

Carlin, Aaron F. ;

Greenbaum, Jason A. ;

Peters, Bjoern ;

Krammer, Florian ;

Smith, Davey M. ;

Crotty, Shane ;

Sette, Alessandro .

CELL, 2020, 181 (07) :1489-+

[10] SARS-CoV-2 antibody prevalence in Brazil: results from two successive nationwide serological household surveys [J].

Hallal, Pedro C. ;

Hartwig, Fernando P. ;

Horta, Bernardo L. ;

Silveira, Mariangela F. ;

Struchiner, Claudio J. ;

Vidaletti, Luis P. ;

Neumann, Nelson A. ;

Pellanda, Lucia C. ;

Dellagostin, Odir A. ;

Burattini, Marcelo N. ;

Victora, Gabriel D. ;

Menezes, Ana M. B. ;

Barros, Fernando C. ;

Barros, Aluisio J. D. ;

Victora, Cesar G. .

LANCET GLOBAL HEALTH, 2020, 8 (11) :E1390-E1398

← 1 2 3 4 5 →