Heparin induced thrombocytopenia: position paper from the Italian Society on Thrombosis and Haemostasis (SISET)

被引：17

作者：

Marcucci, Rossella ^{[1
,2
]}

Berteotti, Martina ^{[1
,2
]}

Gori, Anna M. ^{[1
,2
]}

Giusti, Betti ^{[1
,2
]}

Rogolino, Angela A. ^{[1
,2
]}

Sticchi, Elena ^{[1
,2
]}

Liotta, Agatina Alessandrello ^{[1
,2
]}

Ageno, Walter ^{[3
]}

De Candia, Erica ^{[4
,5
]}

Gresele, Paolo ^{[6
]}

Marchetti, Marina ^{[7
]}

Marietta, Marco ^{[8
]}

Tripodi, Armando ^{[9
,10
]}

机构：

[1] Univ Florence, Expt & Clin Med, Florence, Italy

[2] AOU Careggi Florence, Atherothrombot Ctr, Florence, Italy

[3] Univ Insubria, Dept Med & Surg, Varese, Italy

[4] Univ Cattolica Sacro Cuore, Dept Translat Med & Surg, Rome, Italy

[5] Fdn Policlin Univ Agostino Gemelli IRCCS, Dept Image Diagnost Radiotherapy & Haematol, Rome, Italy

[6] Univ Perugia, Dept Med, Sect Internal & Cardiovasc Med, Perugia, Italy

[7] Hosp Papa Giovanni XXIII, Dept Immunohematol & Transfus Med, Bergamo, Italy

[8] Univ Hosp, Dept Oncol & Haematol, Modena, Italy

[9] IRCCS Ca Granda Maggiore Hosp Fdn, Angelo Bianchi Bon Haemophilia, Milan, Italy

[10] Fdn Luigi Villa, Milan, Italy

来源：

BLOOD TRANSFUSION | 2021年 / 19卷 / 01期

关键词：

platelets; thrombocytopenia; heparin; argatroban; danaparoid; fondaparinux; DIRECT ORAL ANTICOAGULANTS; MOLECULAR-WEIGHT HEPARIN; VENOUS THROMBOEMBOLISM; 4TS SCORE; PLATELET-ACTIVATION; CLINICAL-OUTCOMES; RISK-FACTORS; HEP SCORE; FONDAPARINUX; ARGATROBAN;

D O I：

10.2450/2020.0248-20

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Heparin induced thrombocytopenia (HIT) is a rare immune mediated adverse drug reaction occurring after exposure to heparin. It is a serious and potentially fatal condition, which may be associated with the development of arterial or venous thrombotic events. Although known for many years, HIT is stilt often misdiagnosed. Pretest clinical probability, screening for anti-PF4/heparin antibodies and documentation of their platelet activating capacity are the cornerstones of diagnosis. However, both clinical algorithms and test modalities have limited predictive values and limited diffusion so that the diagnosis and management is challenging in the clinical practice. For this reason, there is an unmet need for novel rational non-anticoagulant therapies based on the pathogenesis of HIT. The present paper reports the position of the Italian Society on Haemostasis and Thrombosis (SISET) in order to increase awareness of HIT among clinicians and other health care professionals and to provide information on the most appropriate management.

引用

页码：14 / 23

页数：10