Chromosome replication origins: Do we really need them?

被引:9
作者
Michel, Benedicte [1 ,2 ]
Bernander, Rolf [3 ]
机构
[1] CNRS, Ctr Genet Mol, Gif Sur Yvette, France
[2] Univ Paris 11, Orsay, France
[3] Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, S-10691 Stockholm, Sweden
基金
瑞典研究理事会;
关键词
archaea; bacteria; RadA; recombination; replication initiation; replication origin; DNA-REPLICATION; HOMOLOGOUS RECOMBINATION; PROTEIN; PRIA; MECHANISMS; INITIATION; EVOLUTION; ORGANIZATION; MUTATIONS;
D O I
10.1002/bies.201400003
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Replication of the main chromosome in the halophilic archaeon Haloferax volcanii was recently reported to continue despite deletion of all active replication origins. Equally surprising, the deletion strain grew faster than the parent strain. It was proposed that origin-less H. volcanii duplicate their chromosomes via recombination-dependent replication. Here, we recall our present knowledge of this mode of chromosome replication in different organisms. We consider the likelihood that it accounts for the viability of H. volcanii deleted for its main specific replication origins, as well as possible alternative interpretations of the results. The selective advantages of having defined chromosome replication origins are discussed from a functional and evolutionary perspective.
引用
收藏
页码:585 / 590
页数:6
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