Diazinium salts with dihydroxyacetophenone skeleton: Syntheses and antimicrobial activity

被引：49

作者：

Balan, Ana Maria ^{[1
]}

Florea, Ondina ^{[1
]}

Moldoveanu, Costel ^{[1
]}

Zbancioc, Gheorghita ^{[1
]}

Iurea, Dorina ^{[1
]}

Mangalagiu, Ionel I. ^{[1
]}

机构：

[1] Alexandru Ioan Cuza Univ, Organ & Biochem Dept, Iasi 700506, Romania

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2009年 / 44卷 / 05期

关键词：

Diazine salts; Microwave; Ultrasounds; Antimicrobial activity;

D O I：

10.1016/j.ejmech.2008.06.017

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Herein we report a feasible study concerning syntheses, structure and antimicrobial activity of some new diazinium salts with dihydroxyacetophenone skeleton. A fast, general, environmentally friendly, and facile method for preparation of diazinium salts under microwave and ultrasounds irradiation is presented. Antimicrobial tests prove that some diazine compounds have a remarkable activity against different microorganisms (germs and fungi), the pyrimidine derivatives being more active. Correlations between structure and antimicrobial activity are reported. (C) 2008 Elsevier Masson SAS. All rights reserved.

引用

页码：2275 / 2279

页数：5

共 11 条

[1] 3,4-DIHYDROXYPHENACYL CHLORIDE QUATERNARY SALTS OF HETEROCYCLIC NITROGEN COMPOUNDS [J].

BAHNER, CT ;

KINDER, H .

JOURNAL OF ORGANIC CHEMISTRY, 1962, 27 (04) :1464-&

[2]

Caprosu MD, 2005, HETEROCYCLES, V65, P1871

[3]

Cruickshank R., 1975, Medicinal Microbiology, VII, P196

[4] New approaches toward anti-HIV chemotherapy [J].

De Clercq, E .

JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (05) :1297-1313

[5] Some pyrrole substituted aryl pyridazinone and phthalazinone derivatives and their antihypertensive activities [J].

Demirayak, S ;

Karaburun, AC ;

Beis, R .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2004, 39 (12) :1089-1095

[6] Development of integrase inhibitors for treatment of AIDS: An overview [J].

Dubey, Sonal ;

Satyanarayana, Y. D. ;

Lavania, Harshita .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2007, 42 (09) :1159-1168

[7] Controlled microwave heating in modern organic synthesis [J].

Kappe, CO .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (46) :6250-6284

[8]

Kappe CO, 2005, METH PRIN MED CHEM, V52, P1, DOI 10.1002/3527606556

[9] Synthesis, biological evaluation, and molecular modeling studies of a novel peripherally selective inhibitor of catechol-O-methyltransferase [J].

Learmonth, DA ;

Palma, PN ;

Vieira-Coelho, MA ;

Soares-da-Silva, P .

JOURNAL OF MEDICINAL CHEMISTRY, 2004, 47 (25) :6207-6217

[10]

Lehn J.-M., 1995, Supramolecular Chemistry-Concepts and Perspectives

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