Osteoclasts are present in gp130-deficient mice

被引:74
作者
Kawasaki, K
Gao, YH
Yokose, S
Kaji, Y
Nakamura, T
Suda, T
Yoshida, K
Taga, T
Kishimoto, T
Kataoka, H
Yuasa, T
Norimatsu, H
Yamaguchi, A
机构
[1] SHOWA UNIV, SCH DENT, DEPT ORAL PATHOL, SHINAGAWA KU, TOKYO 142, JAPAN
[2] SHOWA UNIV, SCH DENT, DEPT BIOCHEM, TOKYO 142, JAPAN
[3] KAGAWA MED SCH, DEPT ORTHOPED SURG, KAGAWA 76107, JAPAN
[4] UNIV OCCUPAT & ENVIRONM HLTH, SCH MED, DEPT ORTHOPED SURG, FUKUOKA 807, JAPAN
[5] OSAKA UNIV, INST MOL & CELLULAR BIOL, OSAKA 565, JAPAN
[6] OSAKA UNIV, SCH MED, DEPT MED 3, OSAKA 565, JAPAN
[7] JUNTENDO UNIV, SCH MED, DEPT ORTHOPED SURG, TOKYO, JAPAN
关键词
D O I
10.1210/en.138.11.4959
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Interleukin (IL)-6, IL-11, leukemia inhibitory factor, and oncostatin M similarly induce osteoclast formation in cocultures of osteoblastic cells and bone marrow cells. These cytokines share a common signal transducer, gp130, which forms a receptor complex with the specific receptor for each cytokine. To investigate the role of gp130 in osteoclast development, we examined bone tissues in gp130-deficient and wild-type newborn mice of the ICR background. Soft x-ray radiographs and microfocus x-ray computed tomographs revealed that bone marrow cavities were present in tibiae and radii of both wildtype and gp130-deficient mice. Microfocus x-ray computed tomography and histological examination demonstrated a decrease in the amount of trabeculae at the metaphysial region in tibiae and radii of the gp130-deficient mice compared with the wild-type mice. The number of osteoclasts in gp130-deficient mice was about double that in the wild-type mice. There were no apparent differences in the distributions of alkaline phosphatase-positive osteoblasts and the osteoid surface on the trabecular bone at the metaphysial region between the wild-type and gp130-deficient mice. The volume of mineralized trabecular bones was also decreased at mandibulae, accompanied by the increased number of osteoclasts in gp130-deficient mice compared with the wild-type and heterozygous mice. These results suggest that the formation of osteoclasts is not solely dependent on gp130 signaling, at least during fetal development. The osteoclastic bone resorption in gp130-deficient mice may be caused by the functional redundancy of bone-resorbing hormones and cytokines other than those of the IL-6 family.
引用
收藏
页码:4959 / 4965
页数:7
相关论文
共 22 条
  • [1] Detection of receptors for interleukin-6, interleukin-11, leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor in bone marrow stromal osteoblastic cells
    Bellido, T
    Stahl, N
    Farruggella, TJ
    Borba, V
    Yancopoulos, GD
    Manolagas, SC
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1996, 97 (02) : 431 - 437
  • [2] INTERLEUKIN-11 - A NEW CYTOKINE CRITICAL FOR OSTEOCLAST DEVELOPMENT
    GIRASOLE, G
    PASSERI, G
    JILKA, RL
    MANOLAGAS, SC
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1994, 93 (04) : 1516 - 1524
  • [3] ISHIMI Y, 1990, J IMMUNOL, V145, P3297
  • [4] Oncostatin-M: A new bone active cytokine that activates osteoblasts and inhibits bone resorption
    Jay, PR
    Centrella, M
    Lorenzo, J
    Bruce, AG
    Horowitz, MC
    [J]. ENDOCRINOLOGY, 1996, 137 (04) : 1151 - 1158
  • [5] INCREASED OSTEOCLAST DEVELOPMENT AFTER ESTROGEN LOSS - MEDIATION BY INTERLEUKIN-6
    JILKA, RL
    HANGOC, G
    GIRASOLE, G
    PASSERI, G
    WILLIAMS, DC
    ABRAMS, JS
    BOYCE, B
    BROXMEYER, H
    MANOLAGAS, SC
    [J]. SCIENCE, 1992, 257 (5066) : 88 - 91
  • [6] BONE MORPHOGENETIC PROTEIN-2 CONVERTS THE DIFFERENTIATION PATHWAY OF C2C12 MYOBLASTS INTO THE OSTEOBLAST LINEAGE
    KATAGIRI, T
    YAMAGUCHI, A
    KOMAKI, M
    ABE, E
    TAKAHASHI, N
    IKEDA, T
    ROSEN, V
    WOZNEY, JM
    FUJISAWASEHARA, A
    SUDA, T
    [J]. JOURNAL OF CELL BIOLOGY, 1994, 127 (06) : 1755 - 1766
  • [7] CYTOKINE SIGNAL-TRANSDUCTION
    KISHIMOTO, T
    TAGA, T
    AKIRA, S
    [J]. CELL, 1994, 76 (02) : 253 - 262
  • [8] KITAMURA H, 1995, AM J PATHOL, V147, P1682
  • [9] LORENZO J A, 1990, Cytokine, V2, P266, DOI 10.1016/1043-4666(90)90027-Q
  • [10] MALIK N, 1995, MOL CELL BIOL, V15, P2349