Colorectal cancer and hypercoagulability

被引：58

作者：

Kawai, Kazushige ^{[1
]}

Watanabe, Toshiaki ^{[1
]}

机构：

[1] Univ Tokyo, Fac Med, Dept Surg Oncol, Bunkyo Ku, Tokyo 1130033, Japan

来源：

SURGERY TODAY | 2014年 / 44卷 / 05期

关键词：

Hypercoagulability; Colorectal cancer; Platelets; Fibrinogen; D-dimer; TISSUE FACTOR EXPRESSION; PROTHROMBIN FRAGMENT F1+2; VON-WILLEBRAND-FACTOR; CARCINOMA DLD1 CELLS; D-DIMER LEVELS; VENOUS THROMBOEMBOLISM; PROGNOSTIC VALUE; CURATIVE RESECTION; ENDOTHELIAL-CELLS; PLASMA-LEVELS;

D O I：

10.1007/s00595-013-0606-5

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Since the first report of the spontaneous appearance of venous thrombophlebitis as a sign of visceral cancer by Trousseau in 1865, many other studies have documented the existence of cancer-associated coagulation disorders. In this review, we describe the hypercoagulable state associated with colorectal cancer, from three perspectives: first, the incidence, risk factors and prevention of clinically symptomatic thromboembolic conditions associated with cancer, such as venous thromboembolism and arterial thrombosis; second, the association between hypercoagulable conditions, such as thrombocytosis, hyperfibrinogenemia, or d-dimer elevation, and the clinical progression and poor prognosis of cancer patients; third, the experimental approach to elucidate the role of various coagulation-related factors in the process of cancer progression, focusing specifically on the role of platelets and tissue factors.

引用

页码：797 / 803

页数：7

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