The Expression of Aldehyde Dehydrogenase Family in Breast Cancer

被引：18

作者：

Qiu, Yan ^{[1
]}

Pu, Tianjie ^{[1
]}

Li, Li ^{[2
]}

Cheng, Fei ^{[2
]}

Lu, Changli ^{[1
]}

Sun, Linyong ^{[1
]}

Teng, Xiao ^{[1
]}

Ye, Feng ^{[1
]}

Bu, Hong ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp, Dept Pathol, Chengdu 610041, Peoples R China

[2] Sichuan Univ, West China Hosp, Key Lab Transplant Engn & Immunol, Chengdu 610041, Peoples R China

来源：

JOURNAL OF BREAST CANCER | 2014年 / 17卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Breast neoplasms; Metastasis; Neoplastic stem cells; Prognosis; STEM-CELLS; PROSPECTIVE IDENTIFICATION; MARKER; PREDICTOR; CARCINOMA;

D O I：

10.4048/jbc.2014.17.1.54

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose: It is widely accepted that aldehyde dehydrogenase (ALDH) activity is a signature of breast cancer stem cells, and high activity has been reported to be associated with poor clinical outcome. The aim of this study was to assess the expression of members of the ALDH family of isozymes in breast cancer tissues and to evaluate the implications of the results. Methods: We analyzed paraffin-embedded tumor tissue from 160 patients with breast cancer. Immunohistochemistry (IHC) staining was performed on the slides using antibodies against different ALDH family members. We collated the IHC results with patient clinical characteristics and determined their prognostic value. In addition, we analyzed normal, hyperplastic, and carcinomatous tissues in situ to check their ALDH distributions. Results: All the tested ALDH members were detected in the various tissue types, but at different levels. Only ALDH 1A3 was found to be significantly associated with distant metastasis (p=0.001), disease-free survival (p<0.001), and overall survival (p<0.001). Conclusion: The level of ALDH 1A3 in breast cancer tissue is a predictive marker of a poor clinical outcome.

引用

页码：54 / 60

页数：7

共 26 条

[1] Prospective identification of tumorigenic breast cancer cells [J].

Al-Hajj, M ;

Wicha, MS ;

Benito-Hernandez, A ;

Morrison, SJ ;

Clarke, MF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) :3983-3988

[2]

[Anonymous], 2012, CANC TREATM SURV FAC

[3] Breast-cancer stem cells-beyond semantics [J].

Badve, Sunil ;

Nakshatri, Harikrishna .

LANCET ONCOLOGY, 2012, 13 (01) :E43-E48

[4] The Malignant Pleural Effusion as a Model to Investigate Intratumoral Heterogeneity in Lung Cancer [J].

Basak, Saroj K. ;

Veena, Mysore S. ;

Oh, Scott ;

Huang, Ge ;

Srivatsan, Eri ;

Min Huang ;

Sharma, Sherven ;

Batra, Raj K. .

PLOS ONE, 2009, 4 (06)

[5] Selection of Tumorigenic Melanoma Cells Using ALDH [J].

Boonyaratanakornkit, Jim B. ;

Yue, Lili ;

Strachan, Lauren R. ;

Scalapino, Kenneth J. ;

LeBoit, Philip E. ;

Lu, Ying ;

Leong, Stanley P. ;

Smith, Janellen E. ;

Ghadially, Ruby .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2010, 130 (12) :2799-2808

[6] Aldehyde Dehydrogenase-Expressing Colon Stem Cells Contribute to Tumorigenesis in the Transition from Colitis to Cancer [J].

Carpentino, Joseph E. ;

Hynes, Mark J. ;

Appelman, Henry D. ;

Zheng, Tong ;

Steindler, Dennis A. ;

Scott, Edward W. ;

Huang, Emina H. .

CANCER RESEARCH, 2009, 69 (20) :8208-8215

[7] SINGLE-MARKER IDENTIFICATION OF HEAD AND NECK SQUAMOUS CELL CARCINOMA CANCER STEM CELLS WITH ALDEHYDE DEHYDROGENASE [J].

Clay, Matthew R. ;

Tabor, Mark ;

Owen, John Henry ;

Carey, Thomas E. ;

Bradford, Carol R. ;

Wolf, Gregory T. ;

Wicha, Max S. ;

Prince, Mark E. .

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2010, 32 (09) :1195-1201

[8] Immunohistochemical analysis of cancer stem cell markers in invasive breast carcinoma and associated ductal carcinoma in situ: relationships with markers of tumor hypoxia and microvascularity [J].

Currie, Margaret J. ;

Beardsley, Brooke E. ;

Harris, Gavin C. ;

Gunningham, Sarah P. ;

Dachs, Gabi U. ;

Dijkstra, Birgit ;

Morrin, Helen R. ;

Wells, J. Elisabeth ;

Robinson, Bridget A. .

HUMAN PATHOLOGY, 2013, 44 (03) :402-411

[9] Distinct Expression Levels and Patterns of Stem Cell Marker, Aldehyde Dehydrogenase Isoform 1 (ALDH1), in Human Epithelial Cancers [J].

Deng, Shan ;

Yang, Xiaojun ;

Lassus, Heini ;

Liang, Shun ;

Kaur, Sippy ;

Ye, Qunrui ;

Li, Chunsheng ;

Wang, Li-Ping ;

Roby, Katherine F. ;

Orsulic, Sandra ;

Connolly, Denise C. ;

Zhang, Youcheng ;

Montone, Kathleen ;

Butzow, Ralf ;

Coukos, George ;

Zhang, Lin .

PLOS ONE, 2010, 5 (04)

[10] Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy [J].

Fillmore, Christine M. ;

Kuperwasser, Charlotte .

BREAST CANCER RESEARCH, 2008, 10 (02)

← 1 2 3 →