Laryngeal Neuroendocrine Carcinoma: A Population-Based Analysis of Incidence and Survival

被引:16
作者
Ghosh, Ritam [1 ]
Dutta, Rahul [1 ]
Dubal, Pariket M. [1 ]
Park, Richard Chan [1 ]
Baredes, Soly [1 ,2 ]
Eloy, Jean Anderson [1 ,2 ,3 ,4 ]
机构
[1] Rutgers New Jersey Med Sch, Dept Otolaryngol Head & Neck Surg, Newark, NJ 07103 USA
[2] Rutgers New Jersey Med Sch, Neurol Inst New Jersey, Ctr Skull Base & Pituitary Surg, Newark, NJ 07103 USA
[3] Rutgers New Jersey Med Sch, Dept Neurol Surg, Newark, NJ 07103 USA
[4] Rutgers New Jersey Med Sch, Dept Ophthalmol & Visual Sci, Newark, NJ 07103 USA
关键词
neuroendocrine carcinoma; malignancy; SEER; demographic; incidence; disease-specific survival; laryngeal carcinoma; laryngeal malignancy; throat cancer; laryngeal neuroendocrine carcinoma; NEOPLASMS; TUMOR; SERIES;
D O I
10.1177/0194599815594386
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Objective Laryngeal neuroendocrine carcinoma (LNEC) is a rare malignancy with various subtypes, each with different characteristics. Classification of these subtypes is used to delineate treatment and management, as most are clinically aggressive with poor prognosis. This study analyzes the characteristics and survival outcomes of LNEC using population-based data. Study Design Analysis of a population-based tumor registry. Setting Academic medical center. Subjects and Methods The Surveillance, Epidemiology, and End Results (SEER) database (1973-2011) was queried for LNEC cases. Data analyzed included patient demographics, incidence, treatment modality, and survival. Results In total, 257 LNEC cases were extracted from the SEER database. Sixty-three percent were male, and the mean age of diagnosis was 61.9 years. Most cases were located in the supraglottis (62.6%), were of the small cell carcinoma (52.9%) histologic subtype, and were grade IV (40.9%) and American Joint Committee on Cancer (AJCC) stage IV (59.4%). Surgery and radiotherapy were used as treatment modalities in 38.3% and 59.8% of patients, respectively. Overall 5-year disease-specific survival (DSS) for all LNEC was 30.2%, with lower grade, lower AJCC stage, and treatment with surgery having higher 5-year DSS. Conclusions LNEC often presents as an aggressive tumor at an advanced stage and has poor survival outcomes. Poor prognostic factors include high histologic grade, advanced stage disease, and not undergoing surgical resection. LNEC may be best treated depending on its histologic differentiation, with surgery being beneficial for early grade tumors while radiotherapy is inconclusive in its benefit for late-stage disease.
引用
收藏
页码:966 / 972
页数:7
相关论文
共 21 条
  • [1] Primary neuroendocrine neoplasms of the larynx. A series of 4 cases reported and a review of the literature
    Angouridakis, Nikolaos
    Goudakos, John
    Karayannopoulou, Georgia
    Triaridis, Stefanos
    Nikolaou, Angelos
    Markou, Konstantinos
    [J]. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2013, 35 (06): : E187 - E193
  • [2] CARCINOID (NEUROENDOCRINE CARCINOMA) OF THE LARYNX
    BAUGH, RF
    WOLF, GT
    MCCLATCHEY, KD
    LLOYD, RV
    EVANS, DA
    [J]. ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY, 1987, 96 (03) : 315 - 321
  • [3] BLANCHARD CL, 1955, ARCHIV OTOLARYNGOL, V61, P472
  • [4] Caric T, 2012, COLLEGIUM ANTROPOL, V36, P173
  • [5] Cevizci Rasit, 2010, Kulak Burun Bogaz Ihtis Derg, V20, P305
  • [6] Endoscopic CO2 laser surgery for an atypical carcinoid tumor of the epiglottis masquerading as a supraglottic cyst
    Chang, KP
    Lee, LY
    Yeh, ARM
    Dai, TS
    Hao, SP
    [J]. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2005, 27 (11): : 1004 - 1007
  • [7] Neuroendocrine carcinomas of the larynx: what do the different histologic types really mean?
    Devaney, Kenneth O.
    Ferlito, Alfio
    Rinaldo, Alessandra
    [J]. EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 2010, 267 (09) : 1323 - 1325
  • [8] CARCINOID-TUMOR OF THE LARYNX - A REPORT OF 2 CASES
    DUVALL, E
    JOHNSTON, A
    MCLAY, K
    PIRIS, J
    [J]. JOURNAL OF LARYNGOLOGY AND OTOLOGY, 1983, 97 (11) : 1073 - 1080
  • [9] Neuroendocrine neoplasms of the larynx: Advances in identification, understanding, and management
    Ferlito, Alfio
    Devaney, Kenneth O.
    Rinaldo, Alessandra
    [J]. ORAL ONCOLOGY, 2006, 42 (08) : 770 - 788
  • [10] NEUROENDOCRINE NEOPLASMS OF THE LARYNX: AN OVERVIEW
    Ferlito, Alfio
    Silver, Carl E.
    Bradford, Carol R.
    Rinaldo, Alessandra
    [J]. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2009, 31 (12): : 1634 - 1646