MHC class I chain-related gene A transmembrane polymorphism in Spanish women with breast cancer

被引：20
作者：
Lavado-Valenzuela, R. [1 ]
Benavides, M. [2 ]
Carabantes, F. [2 ]
Alonso, A. [1 ]
Caballero, A. [1 ]
机构：
[1] Carlos Haya Reg Univ Hosp, Serv Immunol, Malaga 29010, Spain
[2] Carlos Haya Reg Univ Hosp, Med Oncol Sect, Malaga 29010, Spain
来源：
TISSUE ANTIGENS | 2009年 / 74卷 / 01期
关键词：
breast cancer; HLA-B7; MICA; polymorphisms; susceptibility and protection; MICA-A5.1; ALLELE; NK CELLS; T-CELLS; NKG2D; MICA; EXPRESSION; SUSCEPTIBILITY; RECOGNITION; ASSOCIATION; JAPANESE;
D O I：
10.1111/j.1399-0039.2009.01254.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The NKG2D-major histocompatibility complex class I-related chain A (MICA) system plays a key role in the antitumoral immune response. We studied five alleles of a microsatellite in the MICA transmembrane region; one of which (MICA-A5.1) gives rise to a truncated protein. The MICA-A5 allele was reduced in breast cancer patients compared with healthy controls (P = 0.04). Given the association between the HLA-B7 allele and the susceptibility to breast cancer in our area, we also analyzed the distribution of the frequency of the MICA alleles in human leukocyte antigen (HLA)-B7 patients compared with patients with the other alleles. The MICA-A5.1 allele was increased in HLA-B7 patients (P = 0.0003). These results suggest that the MICA-A5 allele appears to confer protection against human breast cancer and that the MICA-A5.1 appears to increase the susceptibility to breast cancer in HLA-B7 patients in our area.
引用
收藏
页码：46 / 49
页数：4
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