The effect of PEG concentration on the release rate of cisplatin from PEG-modified silica xerogels

被引：9

作者：

Czarnobaj, Katarzyna ^{[1
]}

Prokopowicz, Magdalena ^{[1
]}

Lukasiak, Jerzy ^{[1
]}

机构：

[1] Med Univ Gdansk, Dept Phys Chem, Instrumental Anal Lab, PL-80416 Gdansk, Poland

来源：

DRUG DELIVERY | 2006年 / 13卷 / 05期

关键词：

cisplatin; controlled release; polyethylene glycol; silica xerogels; sol-gel method;

D O I：

10.1080/10717540500394752

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cisplatin-an antineoplastic medicine-was incorporated into a polyethylene glycol (PEG)-modified silica xerogels received by the sol-gel method. The influence of PEG concentration and drying temperature on the release of cisplatin was studied. From our results we may state that addition of PEG (M-W 600) and drying of silica xerogels at 80 degrees C augmented the release of cisplatin. The release of cisplatin from the matrices grows with the increase of PEG volume in xerogel (up to 74-97% within 7 days), whereas application of thermal drying resulted in both increased speed and amount of the drug released up to 91-97% within 2 days.

引用

页码：339 / 344

页数：6

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