The effect of PEG concentration on the release rate of cisplatin from PEG-modified silica xerogels

被引：9
|
作者：
Czarnobaj, Katarzyna [1 ]
Prokopowicz, Magdalena [1 ]
Lukasiak, Jerzy [1 ]
机构：
[1] Med Univ Gdansk, Dept Phys Chem, Instrumental Anal Lab, PL-80416 Gdansk, Poland
来源：
DRUG DELIVERY | 2006年 / 13卷 / 05期
关键词：
cisplatin; controlled release; polyethylene glycol; silica xerogels; sol-gel method;
D O I：
10.1080/10717540500394752
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Cisplatin-an antineoplastic medicine-was incorporated into a polyethylene glycol (PEG)-modified silica xerogels received by the sol-gel method. The influence of PEG concentration and drying temperature on the release of cisplatin was studied. From our results we may state that addition of PEG (M-W 600) and drying of silica xerogels at 80 degrees C augmented the release of cisplatin. The release of cisplatin from the matrices grows with the increase of PEG volume in xerogel (up to 74-97% within 7 days), whereas application of thermal drying resulted in both increased speed and amount of the drug released up to 91-97% within 2 days.
引用
收藏
页码：339 / 344
页数：6
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