The Biology of Chronic Graft-versus-Host Disease: A Task Force Report from the National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease

被引：306

作者：

Cooke, Kenneth R. ^{[1
]}

Luznik, Leo ^{[1
]}

Sarantopoulos, Stefanie ^{[2
,3
]}

Hakim, Frances T. ^{[4
]}

Jagasia, Madan ^{[5
]}

Fowler, Daniel H. ^{[4
]}

van den Brink, Marcel R. M. ^{[6
,7
]}

Hansen, John A. ^{[8
]}

Parkman, Robertson ^{[9
]}

Miklos, David B. ^{[10
]}

Martin, Paul J. ^{[8
]}

Paczesny, Sophie ^{[11
,12
]}

Vogelsang, Georgia ^{[1
]}

Pavletic, Steven ^{[4
]}

Ritz, Jerome ^{[13
]}

Schultz, Kirk R. ^{[14
]}

Blazar, Bruce R. ^{[15
,16
]}

机构：

[1] Johns Hopkins Univ Hosp, Dept Oncol, Sidney Kimmel Canc Ctr, Baltimore, MD 21287 USA

[2] Duke Univ, Div Hematol Malignancies & Cellular Therapy, Dept Immunol, Durham, NC USA

[3] Duke Univ, Duke Canc Inst, Durham, NC USA

[4] NCI, Expt Transplantat & Immunol Branch, Ctr Canc Res, Bethesda, MD 20892 USA

[5] Vanderbilt Univ, Dept Med, Med Ctr, Div Hematol Oncol, Nashville, TN USA

[6] Mem Sloan Kettering Canc Ctr, Dept Immunol, New York, NY 10021 USA

[7] Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA

[8] Univ Washington, Dept Med, Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA USA

[9] Stanford Univ, Div Pediat Stem Cell Transplantat & Regenerat Med, Palo Alto, CA 94304 USA

[10] Stanford Univ, Div Blood & Marrow Transplantat, Palo Alto, CA 94304 USA

[11] Indiana Univ Sch Med, Wells Ctr Pediat Res, Dept Pediat, Melvin & Bren Simon Canc Ctr, Indianapolis, IN 46202 USA

[12] Indiana Univ Sch Med, Wells Ctr Pediat Res, Dept Immunol, Melvin & Bren Simon Canc Ctr, Indianapolis, IN 46202 USA

[13] Harvard Med Sch, Dana Farber Canc Inst, Div Hematol Malignancies, Boston, MA USA

[14] Univ British Columbia, Dept Pediat, Michael Cuccione Childhood Canc Res Program, BC Childrens Hosp, Vancouver, BC, Canada

[15] Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN 55455 USA

[16] Univ Minnesota, Dept Pediat, Div Blood & Marrow Transplantat, Minneapolis, MN 55455 USA

来源：

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | 2017年 / 23卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Chronic graft-versus-host disease; Blood and marrow transplantation; lmmune mechanisms; Clinical manifestations; REGULATORY T-CELLS; BONE-MARROW-TRANSPLANTATION; MINOR HISTOCOMPATIBILITY ANTIGENS; NECROSIS-FACTOR-ALPHA; NONINFECTIOUS PULMONARY COMPLICATIONS; BRONCHIOLITIS OBLITERANS SYNDROME; SYSTEMIC-LUPUS-ERYTHEMATOSUS; CD19(+)CD21(LOW) B-CELLS; FOLLICULAR HELPER-CELLS; MURINE CHRONIC GVHD;

D O I：

10.1016/j.bbmt.2016.09.023

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Chronic graft-versus-host disease (GVHD) is the leading cause of late, nonrelapse mortality and disability in allogeneic hematopoietic cell transplantation recipients and a major obstacle to improving outcomes. The biology of chronic GVHD remains enigmatic, but understanding the underpinnings of the immunologic mechanisms responsible for the initiation and progression of disease is fundamental to developing effective prevention and treatment strategies. The goals of this task force review are as follows: Summarize the current state of the science regarding pathogenic mechanisms of chronic GVHD and critical knowledge gaps. Develop Working hypotheses overriding concepts for chronic GVHD development. Define the usefulness of current preclinical models to test working hypotheses and ultimately discover and develop new therapeutic strategies. Identify shortcomings of preclinical models, and define criteria for the creation of additional models to address these limitations. This document is intended as a review of our understanding of chronic GVHD biology and therapies resulting from preclinical studies, and as a platform for developing innovative clinical strategies to prevent and treat chronic GVHD. Published by Elsevier Inc. on behalf of the American Society for Blood and Marrow Transplantation.

引用

页码：211 / 234

页数：24

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