Novel coronavirus disease 2019 (COVID-19) has resulted in a global pandemic and is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Several studies have suggested that a precise disulfide-thiol balance is crucial for viral entry and fusion into the host cell and that oxidative stress generated from free radicals can affect this balance. Here, we reviewed the current knowledge about the role of oxidative stress on SARS-CoV and SARS-CoV-2 infections. We focused on the impact of antioxidants, like NADPH and glutathione, and redox proteins, such as thioredoxin and protein disulfide isomerase, that maintain the disulfide-thiol balance in the cell. The possible influence of these biomolecules on the binding of viral protein with the host cell angiotensin-converting enzyme II receptor protein as well as on the severity of COVID-19 infection was discussed.
机构:
Univ Verona, Dept Med, Sect Gen Pathol, Med Sch, Str Le Grazie 8, I-37134 Verona, ItalyUniv Verona, Dept Med, Sect Gen Pathol, Med Sch, Str Le Grazie 8, I-37134 Verona, Italy
Bellavite, Paolo
;
Donzelli, Alberto
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机构:
Fdn Allineare Sanita & Salute, Sci Comm, I-20122 Milan, ItalyUniv Verona, Dept Med, Sect Gen Pathol, Med Sch, Str Le Grazie 8, I-37134 Verona, Italy
机构:
Univ Verona, Dept Med, Sect Gen Pathol, Med Sch, Str Le Grazie 8, I-37134 Verona, ItalyUniv Verona, Dept Med, Sect Gen Pathol, Med Sch, Str Le Grazie 8, I-37134 Verona, Italy
Bellavite, Paolo
;
Donzelli, Alberto
论文数: 0引用数: 0
h-index: 0
机构:
Fdn Allineare Sanita & Salute, Sci Comm, I-20122 Milan, ItalyUniv Verona, Dept Med, Sect Gen Pathol, Med Sch, Str Le Grazie 8, I-37134 Verona, Italy