Role of Oxidative Stress on SARS-CoV (SARS) and SARS-CoV-2 (COVID-19) Infection: A Review

被引:222
作者
Suhail, Shanzay [1 ]
Zajac, Jonathan [1 ]
Fossum, Carl [1 ]
Lowater, Harrison [1 ]
McCracken, Cailin [1 ]
Severson, Nathaniel [1 ]
Laatsch, Bethany [1 ]
Narkiewicz-Jodko, Alex [1 ]
Johnson, Benjamin [1 ]
Liebau, Jessica [1 ]
Bhattacharyya, Sudeep [1 ]
Hati, Sanchita [1 ]
机构
[1] Univ Wisconsin, Dept Chem & Biochem, Eau Claire, WI 54701 USA
关键词
Angiotensin-converting enzyme 2; COVID-19; Oxidative stress; SARS; SARS-CoV2; Spike protein; PROTEIN DISULFIDE-ISOMERASE; SPIKE GLYCOPROTEIN; MEMBRANE-FUSION; VIRUS-INFECTION; CORONAVIRUS; GLUTATHIONE; RECEPTOR; ENTRY; BINDING; ACE2;
D O I
10.1007/s10930-020-09935-8
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Novel coronavirus disease 2019 (COVID-19) has resulted in a global pandemic and is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Several studies have suggested that a precise disulfide-thiol balance is crucial for viral entry and fusion into the host cell and that oxidative stress generated from free radicals can affect this balance. Here, we reviewed the current knowledge about the role of oxidative stress on SARS-CoV and SARS-CoV-2 infections. We focused on the impact of antioxidants, like NADPH and glutathione, and redox proteins, such as thioredoxin and protein disulfide isomerase, that maintain the disulfide-thiol balance in the cell. The possible influence of these biomolecules on the binding of viral protein with the host cell angiotensin-converting enzyme II receptor protein as well as on the severity of COVID-19 infection was discussed.
引用
收藏
页码:644 / 656
页数:13
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