IL-13 receptor α2 stimulates human glioma cell growth and metastasis through the Src/PI3K/Akt/mTOR signaling pathway

被引:50
|
作者
Tu, Ming [1 ]
Wange, Wei [2 ]
Cai, Lin [1 ]
Zhu, Penglei [1 ]
Gao, Zhichao [1 ]
Zheng, Weiming [1 ]
机构
[1] Wenzhou Med Univ, Affiliated Hosp 1, Dept Neurosurg, Wenzhou, Zhejiang, Peoples R China
[2] Wenzhou Med Univ, Affiliated Hosp 2, Dept Emergency, Wenzhou, Zhejiang, Peoples R China
关键词
Glioma; IL-13R alpha 2; Scr; Invasion; CANCER-THERAPY; TARGETED IMMUNOTOXIN; PANCREATIC-CANCER; POOR-PROGNOSIS; ACTIVATION; EXPRESSION; EXOTOXIN; SURVIVAL; INVASION;
D O I
10.1007/s13277-016-5346-x
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Glioma is a malignant tumor that affects all kinds of people all over the world. It demonstrates remarkable infiltrative and invasive features. The high expression of interleukin-13 receptor subunit alpha-2 (IL-13R alpha 2) reportedly plays a pivotal role in some cancers. However, whether IL-13R alpha 2 contributes to glioma remains unknown. This study demonstrates that IL-13R alpha 2 is significantly up-regulated in human glioma tissue samples. It is also associated with late stages of disease progression and diminished survival in glioma patients. Gain-and loss-of-function studies demonstrate that IL-13R alpha 2 promotes the growth, migration, and invasion of glioma cells. In addition, mechanistic investigations show that IL-13R alpha 2 activates Scr, phosphatidylinositol 3 kinase (PI3K), Akt, and mTOR. Also, restraining Scr in glioma cells attenuates the activation of Scr/PI3K/Akt/mTOR pathway by IL-13R alpha 2, whereas the silencing of Scr markedly rescues the proinvasive effect of IL-13R alpha 2. In conclusion, our results suggest that the high expression of IL-13R alpha 2 is significantly associated with the growth and metastasis of human glioma cells via the Scr/PI3K/Akt/mTOR pathway, while IL-13R alpha 2 may be a potential therapeutic target for glioma treatment.
引用
收藏
页码:14701 / 14709
页数:9
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