Relevance of RNA structure for the activity of picornavirus IRES elements

被引：91
|
作者：
Fernandez-Miragall, Olga [1 ]
Lopez de Quinto, Sonia [1 ]
Martinez-Salas, Encarnacion [1 ]
机构：
[1] Univ Autonoma Madrid, CSIC, Ctr Biol Mol Severo Ochoa, E-28049 Madrid, Spain
来源：
VIRUS RESEARCH | 2009年 / 139卷 / 02期
关键词：
Internal translation initiation; Picornavirus infection; RNA structure; RNA-binding proteins; IRES transacting factors; INTERNAL RIBOSOME ENTRY; MOUTH-DISEASE VIRUS; HEPATITIS-C VIRUS; TRACT-BINDING-PROTEIN; TRANSLATION INITIATION-FACTOR; CAP-INDEPENDENT TRANSLATION; 5' UNTRANSLATED REGION; ENCEPHALOMYOCARDITIS VIRUS; IN-VIVO; MESSENGER-RNA;
D O I：
10.1016/j.virusres.2008.07.009
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The RNA of all members of the Picornaviiidae family initiates translation internally, via an internal ribosome entry site (IRES) element present in their 5' untranslated region. IRES elements consist of cis-acting RNA structures that often operate in association with specific RNA-binding proteins to recruit the translational machinery. This specialized mechanism of translation initiation is shared with other viral RNAs, and represents an alternative to the general cap-dependent initiation mechanism. In this review we discuss recent evidences concerning the relationship between RNA structure and IRES function in the genome of picornaviruses. The biological implications of conserved RNA structural elements for the mechanism of internal translation initiation driven by representative members of enterovirus and rhinovirus (type I IRES) and cardiovirus and aphthovirus (type II IRES) will be discussed. (c) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码：172 / 182
页数：11
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