Relevance of RNA structure for the activity of picornavirus IRES elements

被引：90

作者：

Fernandez-Miragall, Olga ^{[1
]}

Lopez de Quinto, Sonia ^{[1
]}

Martinez-Salas, Encarnacion ^{[1
]}

机构：

[1] Univ Autonoma Madrid, CSIC, Ctr Biol Mol Severo Ochoa, E-28049 Madrid, Spain

来源：

VIRUS RESEARCH | 2009年 / 139卷 / 02期

关键词：

Internal translation initiation; Picornavirus infection; RNA structure; RNA-binding proteins; IRES transacting factors; INTERNAL RIBOSOME ENTRY; MOUTH-DISEASE VIRUS; HEPATITIS-C VIRUS; TRACT-BINDING-PROTEIN; TRANSLATION INITIATION-FACTOR; CAP-INDEPENDENT TRANSLATION; 5' UNTRANSLATED REGION; ENCEPHALOMYOCARDITIS VIRUS; IN-VIVO; MESSENGER-RNA;

D O I：

10.1016/j.virusres.2008.07.009

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The RNA of all members of the Picornaviiidae family initiates translation internally, via an internal ribosome entry site (IRES) element present in their 5' untranslated region. IRES elements consist of cis-acting RNA structures that often operate in association with specific RNA-binding proteins to recruit the translational machinery. This specialized mechanism of translation initiation is shared with other viral RNAs, and represents an alternative to the general cap-dependent initiation mechanism. In this review we discuss recent evidences concerning the relationship between RNA structure and IRES function in the genome of picornaviruses. The biological implications of conserved RNA structural elements for the mechanism of internal translation initiation driven by representative members of enterovirus and rhinovirus (type I IRES) and cardiovirus and aphthovirus (type II IRES) will be discussed. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：172 / 182

页数：11

共 118 条

[1] Differential factor requirement to assemble translation initiation complexes at the alternative start codons of foot- and-mouth disease virus RNA [J].

Andreev, Dmitri E. ;

Fernandez-Miragall, Olga ;

Ramajo, Jorge ;

Dmitriev, Sergey E. ;

Terenin, Ilya M. ;

Martinez-Salas, Encarna ;

Shatsky, Ivan N. .

RNA, 2007, 13 (08) :1366-1374

[2]

[Anonymous], J VIROL

[3] Structure of the 5′ nontranslated region of the coxsackievirus B3 genome:: Chemical modification and comparative sequence analysis [J].

Bailey, Jennifer M. ;

Tapprich, William E. .

JOURNAL OF VIROLOGY, 2007, 81 (02) :650-668

[4] DUAL INITIATION SITES OF PROTEIN-SYNTHESIS ON FOOT-AND-MOUTH-DISEASE VIRUS-RNA ARE SELECTED FOLLOWING INTERNAL ENTRY AND SCANNING OF RIBOSOMES INVIVO [J].

BELSHAM, GJ .

EMBO JOURNAL, 1992, 11 (03) :1105-1110

[5] Role of GNRA motif mutations within stem-loop V of internal ribosome entry segment in coxsackievirus B3 molecular attenuation [J].

Ben M'hadheb-Gharbi, Manel ;

El Hiar, Raieda ;

Paulous, Sylvie ;

Jaidane, Hela ;

Aouni, Mahjoub ;

Kean, Katherine M. ;

Gharbi, Jawhar .

JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY, 2008, 14 (04) :147-156

[6] Requirement of Poly(rC) binding protein 2 for translation of poliovirus RNA [J].

Blyn, LB ;

Towner, JS ;

Semler, BL ;

Ehrenfeld, E .

JOURNAL OF VIROLOGY, 1997, 71 (08) :6243-6246

[7] Intact eukaryotic initiation factor 4G is required for hepatitis A virus internal initiation of translation [J].

Borman, AM ;

Kean, KM .

VIROLOGY, 1997, 237 (01) :129-136

[8] Poly(A)-binding protein is differentially required for translation mediated by viral internal ribosome entry sites [J].

Bradrick, Shelton S. ;

Dobrikova, Elena Y. ;

Kaiser, Constanze ;

Shveygert, Mayya ;

Gromeier, Matthias .

RNA, 2007, 13 (09) :1582-1593

[9] FUNCTIONAL-ANALYSIS OF THE 2 ALTERNATIVE TRANSLATION INITIATION SITES OF FOOT-AND-MOUTH-DISEASE VIRUS [J].

CAO, XM ;

BERGMANN, IE ;

FULLKRUG, R ;

BECK, E .

JOURNAL OF VIROLOGY, 1995, 69 (01) :560-563

[10] Comparative genomics of foot-and-mouth disease virus [J].

Carrillo, C ;

Tulman, ER ;

Delhon, G ;

Lu, Z ;

Carreno, A ;

Vagnozzi, A ;

Kutish, GF ;

Rock, DL .

JOURNAL OF VIROLOGY, 2005, 79 (10) :6487-6504

← 1 2 3 4 5 6 7 8 9 10 →