Antinuclear Antibody-Negative Systemic Lupus Erythematosus in an International Inception Cohort

被引：64

作者：

Choi, May Y. ^{[1
]}

Clarke, Ann E. ^{[1
]}

St Pierre, Yvan ^{[2
]}

Hanly, John G. ^{[3
,4
]}

Urowitz, Murray B. ^{[5
]}

Romero-Diaz, Juanita ^{[6
]}

Gordon, Caroline ^{[7
]}

Bae, Sang-Cheol ^{[8
]}

Bernatsky, Sasha ^{[2
]}

Wallace, Daniel J. ^{[9
]}

Merrill, Joan T. ^{[10
]}

Isenberg, David A. ^{[11
]}

Rahman, Anisur ^{[11
]}

Ginzler, Ellen M. ^{[12
]}

Petri, Michelle ^{[13
]}

Bruce, Ian N. ^{[14
,15
]}

Dooley, Mary A. ^{[16
]}

Fortin, Paul R. ^{[17
]}

Gladman, Dafna D. ^{[5
]}

Sanchez-Guerrero, Jorge ^{[18
,19
]}

Steinsson, Kristjan ^{[20
]}

Ramsey-Goldman, Rosalind ^{[21
,22
]}

Khamashta, Munther A. ^{[23
,24
]}

Aranow, Cynthia ^{[25
]}

Alarcon, Graciela S. ^{[26
]}

Manzi, Susan ^{[27
]}

Nived, Ola ^{[28
]}

Zoma, Asad A. ^{[29
]}

van Vollenhoven, Ronald F. ^{[30
]}

Ramos-Casals, Manuel ^{[31
]}

Ruiz-Irastorza, Guillermo ^{[32
]}

Lim, S. Sam ^{[33
]}

Kalunian, Kenneth C. ^{[34
]}

Inanc, Murat ^{[35
]}

Kamen, Diane L. ^{[36
]}

Peschken, Christine A. ^{[37
]}

Jacobsen, Soren ^{[38
]}

Askanase, Anca ^{[39
]}

Stoll, Thomas ^{[40
]}

Buyon, Jill ^{[41
]}

Mahler, Michael ^{[42
]}

Fritzler, Marvin J. ^{[1
]}

机构：

[1] Univ Calgary, Cumming Sch Med, Calgary, AB, Canada

[2] McGill Univ, Hlth Ctr, Montreal, PQ, Canada

[3] Queen Elizabeth 2 Hlth Sci Ctr, Halifax, NS, Canada

[4] Dalhousie Univ, Halifax, NS, Canada

[5] Univ Toronto, Toronto Western Hosp, Toronto, ON, Canada

[6] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Mexico City, DF, Mexico

[7] Univ Birmingham, Birmingham, W Midlands, England

[8] Hanyang Univ, Hosp Rheumat Dis, Seoul, South Korea

[9] Univ Calif Los Angeles, David Geffen Sch Med, Cedars Sinai, Los Angeles, CA 90095 USA

[10] Oklahoma Med Res Fdn, 825 NE 13th St, Oklahoma City, OK 73104 USA

[11] UCL, London, England

[12] NYU, Downstate Med Ctr, Brooklyn, NY USA

[13] Johns Hopkins Univ, Sch Med, Baltimore, MD USA

[14] Univ Manchester, Cent Manchester Univ Hosp NHS Fdn Trust, NIHR Manchester Biomed Res Ctr, Arthrit Res UK, Manchester, Lancs, England

[15] Manchester Acad, Hlth Sci Ctr, Manchester, Lancs, England

[16] Univ N Carolina, Chapel Hill, NC 27515 USA

[17] Univ Laval, CHU Quebec, Quebec City, PQ, Canada

[18] Univ Toronto, Mt Sinai Hosp, Toronto, ON, Canada

[19] Univ Toronto, Univ Hlth Network, Toronto, ON, Canada

[20] Landspitali Univ Hosp, Reykjavik, Iceland

[21] Northwestern Univ, Chicago, IL 60611 USA

[22] Feinberg Sch Med, Chicago, IL USA

[23] St Thomas Hosp, London, England

[24] Kings Coll London, London Sch Med, London, England

[25] Feinstein Inst Med Res, Manhasset, NY USA

[26] Univ Alabama Birmingham, Birmingham, AL USA

[27] Allegheny Hlth Network, Pittsburgh, PA USA

[28] Univ Hosp Lund, Lund, Sweden

[29] Hairmyres Hosp, E Kilbride, Lanark, Scotland

[30] Univ Amsterdam, Amsterdam, Netherlands

[31] Hosp Clin Barcelona, Barcelona, Spain

[32] Univ Basque Country, Hosp Univ Cruces, Baracaldo, Spain

[33] Emory Univ, Sch Med, Atlanta, GA USA

[34] Univ Calif San Diego, Sch Med, La Jolla, CA 92093 USA

[35] Istanbul Univ, Istanbul, Turkey

[36] Med Univ South Carolina, Charleston, SC 29425 USA

[37] Univ Manitoba, Winnipeg, MB, Canada

[38] Copenhagen Univ Hosp, Rigshosp, Copenhagen, Denmark

[39] NYU, Hosp Joint Dis, New York, NY USA

[40] Kantousspital, Schaffhausen, Switzerland

[41] NYU, Sch Med, New York, NY USA

[42] Inova Diagnost Inc, San Diego, CA USA

来源：

ARTHRITIS CARE & RESEARCH | 2019年 / 71卷 / 07期

基金：

加拿大健康研究院; 英国惠康基金;

关键词：

INDIRECT IMMUNOFLUORESCENCE; SS-A/RO; AUTOANTIBODIES; NEPHRITIS; SLE; CRITERIA; CLASSIFICATION; PATHWAYS;

D O I：

10.1002/acr.23712

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective The spectrum of antinuclear antibodies (ANAs) is changing to include both nuclear staining as well as cytoplasmic and mitotic cell patterns (CMPs) and accordingly a change is occurring in terminology to anticellular antibodies. This study examined the prevalence of indirect immunofluorescence (IIF) anticellular antibody staining using the Systemic Lupus International Collaborating Clinics inception cohort. Methods Anticellular antibodies were detected by IIF on HEp-2000 substrate using the baseline serum. Three serologic subsets were examined: ANA positive (presence of either nuclear or mixed nuclear/CMP staining), anticellular antibody negative (absence of any intracellular staining), and isolated CMP staining. The odds of being anticellular antibody negative versus ANA or isolated CMP positive was assessed by multivariable analysis. Results A total of 1,137 patients were included; 1,049 (92.3%) were ANA positive, 71 (6.2%) were anticellular antibody negative, and 17 (1.5%) had an isolated CMP. The isolated CMP-positive group did not differ from the ANA-positive or anticellular antibody-negative groups in clinical, demographic, or serologic features. Patients who were older (odds ratio [OR] 1.02 [95% confidence interval (95% CI) 1.00, 1.04]), of white race/ethnicity (OR 3.53 [95% CI 1.77, 7.03]), or receiving high-dose glucocorticoids at or prior to enrollment (OR 2.39 [95% CI 1.39, 4.12]) were more likely to be anticellular antibody negative. Patients on immunosuppressants (OR 0.35 [95% CI 0.19, 0.64]) or with anti-SSA/Ro 60 (OR 0.41 [95% CI 0.23, 0.74]) or anti-U1 RNP (OR 0.43 [95% CI 0.20, 0.93]) were less likely to be anticellular antibody negative. Conclusion In newly diagnosed systemic lupus erythematosus, 6.2% of patients were anticellular antibody negative, and 1.5% had an isolated CMP. The prevalence of anticellular antibody-negative systemic lupus erythematosus will likely decrease as emerging nomenclature guidelines recommend that non-nuclear patterns should also be reported as a positive ANA.

引用

页码：893 / 902

页数：10

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