Fevers and mouth ulcers

被引：4

作者：

Codarini, M ^{[1
]}

Teo, J ^{[1
]}

机构：

[1] Childrens Hosp Westmead, Dept Immunol & Infect Dis, Westmead, NSW 2145, Australia

来源：

JOURNAL OF PAEDIATRICS AND CHILD HEALTH | 2001年 / 37卷 / 05期

关键词：

D O I：

10.1046/j.1440-1754.2001.00685.x

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

• Mouth ulcers are commonly caused by infection but may be due to neutropenia. • The most common form of hyper-IgM syndrome is of X-linked inheritance and caused by CD40 ligand gene mutations. • Consider hyper-IgM syndrome in a male child with recurrent bacterial or opportunistic infections, neutopenia, hypogammaglobulinaemia (IgG and IgA) and normal T- and B-cell counts. • In X-linked hyper-IgM syndrome: - the serum IgM concentration is normal in about 50% of cases. -transient or persistent neutropenia occurs in 70% of cases. • First-line therapeutic options for hyper-IgM syndrome include regular intravenous immunoglobulin and prophylactic trimethoprimsulphamethoxazole.

引用

页码：507 / 509

页数：3

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