We report the case of a 64-year-old male presenting with chest pain with a history of hyperlipidemia and smoking. Coronary angiogram was not successful to visualize the right coronary artery. Contrast enhanced 64-slice computed tomography (CT) identified the origin of the RCA from the aorta and distal stenosis of the vessel. Additionally, it revealed that the nature of the stenosis could be consistent with soft plaque or thrombus. Repeated coronary angiogram confirmed the data obtained by 64-slice CT. The confirmatory value of 64-slice CT in the evaluation of coronary abnormalities and stenoses has been addressed by this case report.